Sökning: "Depolarization changes"
Visar resultat 6 - 10 av 34 avhandlingar innehållade orden Depolarization changes.
6. Calcium dynamics and vesicle-release proteins in a prion-infected neuronal cell line
Sammanfattning : The prion particle, PrPSc, is an infectious, misfolded form of the cellular prion protein, PrPC that is expressed at high levels in the central nervous system. Prions cause neurodegenerative diseases with clinical signs including dementia, ataxia and myoclonus. These diseases cause characteristic electroencephalographic changes. LÄS MER
7. Ventricular repolarization in the human heart : effects of pharmacological and non-pharmacological interventions
Sammanfattning : Ventricular arrhythmias is the main cause of sudden cardiac death. A prolonged repolarization might cause such arrhythmias, and an increased understanding about mechanisms is therefore important for their primary and secondary prevention. LÄS MER
8. Regulation of insulin secretion in diabetes: Molecular mechanism and applications
Sammanfattning : Diabetes is a highly ageing-related disease manifesting with a deteriorated capacity of insulin secretion and uncontrolled blood glucose-raising, hyperglycemia. In this thesis, we aim to explore the underlying roles of CaV channels and aging-associated genetic changes in the development of Type 2 diabetes (T2D). LÄS MER
9. Cell coupling and exocytosis measured in intact mouse pancreatic islets Control of {delta}-cell secretion
Sammanfattning : Patch-clamp and capacitance measurements were applied to α-, β- and δ-cells in intact mouse pancreatic islets. The maximum rate of β-cell exocytosis during a depolarization to 0 mV was 14 granules/s, ... LÄS MER
10. Voltage sensitivity of dopamine D2-like receptors
Sammanfattning : G protein coupled receptors (GPCRs) mediate a multitude of responses serving hormonal, neurotransmitter, and sensory functions. These receptors are important drug targets; in fact, about 27 % of prescribed drugs are GPCR ligands. LÄS MER