Sökning: "Deepti Verma"

Hittade 2 avhandlingar innehållade orden Deepti Verma.

1. 1. Genetic variations in the NALP3 inflammasome: a susceptibility factor for inflammatory diseases

   Författare :Deepti Verma; Peter Söderkvist; Ulf Andersson; Linköpings universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Inflammasome; Interleukin-1 beta; NALP3; autoinflammation; Medical genetics; Medicinsk genetik;

   Sammanfattning : Innate immunity has received impressive attention in the past decade owing to the discovery of the Toll like receptors (TLRs) and the NOD-like receptors (NLRs). While the TLRs specialize in fighting microbes at the cell surface, the NLRs complement by detecting and responding to intracellular microbes. LÄS MER

3. 2. Genetic Variations in the NLRP3 Inflammasome : Susceptibility Factor for Chronic Inflammation

   Författare :Deepti Verma; Peter Söderkvist; Särndahl Särndahl; Hal Hoffman; Linköpings universitet; []
   Nyckelord :MEDICINE; MEDICIN;

   Sammanfattning : NLRP3 has been recognized as one of the key components of innate immunity. Upon activation, NLRP3 forms a multiprotein complex called as the ‘inflammasome’ which leads to the activation of pro-inflammatory caspase-1 which subsequently results in the formation of Interleukin (IL)-1β and IL-18. LÄS MER