Sökning: "Deep sequencing"

Visar resultat 31 - 35 av 68 avhandlingar innehållade orden Deep sequencing.

  1. 31. Deciphering HIV genetic variability and evolution by massive parallel pyrosequencing and bioinformatics

    Författare :Johanna Brodin; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : HIV-1 is a virus with a very variable genome and therefore has the ability to adapt to new environments which include escape from immune pressure and suboptimal antiretroviral treatment. Next-generation sequencing (NGS), especially ultra-deep pyrosequencing (UDPS), has enabled in-depth sequencing studies with a previously unattainable resolution. LÄS MER

  3. 32. Pan-cancer study of transcriptional responses to oncogenic somatic mutations

    Författare :Arghavan Ashouri; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cancer; Driver mutations; Genomics; Transcriptomics; lncRNAs; NRF2; ALK;

    Sammanfattning : Cancer cells typically carry acquired somatic mutations in key cancer driver genes, which can be identified on the basis of recurrence in cancer cohorts. Such mutations may cause aberrant protein activity and altered gene expression in the nucleus, driving the cell toward a cancerous phenotype. LÄS MER

  4. 33. B cell transcriptomics and immunoglobulin genetics in rheumatoid arthritis

    Författare :Uta Hardt; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Rheumatoid Arthritis (RA) is a complex autoimmune disease characterized by inflammation of the peripheral joints. The exact disease pathology remains to be elucidated, but it has been hypothesized that autoreactive B cells and autoantibodies play a major role in the etiology. LÄS MER

  5. 34. Machine learning and data-parallel processing for viral metagenomics

    Författare :Zurab Bzhalava; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : More than 2 million cancer cases around the world each year are caused by viruses. In addition, there are epidemiological indications that other cancer-associated viruses may also exist. However, the identification of highly divergent and yet unknown viruses in human biospecimens is one of the biggest challenges in bio- informatics. LÄS MER

  7. 35. Genetic Characterization of Pediatric T-cell Acute Lymphoblastic Leukemia

    Författare :Kristina Karrman; Avdelningen för klinisk genetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; leukmia; genetic characterization; pediatric;

    Sammanfattning : The aim of my thesis has been to characterize genetically pediatric T-cell acute lymphoblastic leukemia (T-ALL). Articles I and II focus on molecular characterization of translocations involving T-cell receptor (TCR) loci. LÄS MER