Sökning: "Deep sequencing"

Visar resultat 26 - 30 av 68 avhandlingar innehållade orden Deep sequencing.

1. 26. Measurable residual disease and clonal evolution in acute myeloid leukemia with focus on NPM1-mutations

   Författare :Louise Pettersson; Lund Patologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; AML; MRD; Measurable residual disease; NPM1; NPM1-mutation; NPM1 type A mutation; clonal evolution; clonal patterns; subclones; genetic evolution; qPCR; RQ-PCR; ddPCR; deep seq; deep sequencing; NGS; RT-qPCR; old; elderly; MFC; flow cytometry;

   Sammanfattning : Acute myeloid leukemia (AML) is the most common form of acute leukemia in adults, with mutations in the NPM1 gene occurring in almost one third of all cases. The ability to detect residual leukemia below the resolution of conventional microscopy is crucial for evaluation of relapse risk after therapy. LÄS MER

3. 27. Genome-Wide Studies of Transcriptional Regulation in Mammalian Cells

   Författare :Ola Wallerman; Claes Wadelius; Jussi Taipale; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ChIP; ChIP-chip; ChIP-seq; transcription factors; motif discovery; nucleosome positioning; HepG2; genome-wide; RNA-seq; Medical genetics; Medicinsk genetik; Medical Genetics; Medicinsk genetik;

   Sammanfattning : The key to the complexity of higher organisms lies not in the number of protein coding genes they carry, but rather in the intrinsic complexity of the gene regulatory networks. The major effectors of transcriptional regulation are proteins called transcription factors, and in this thesis four papers describing genome-wide studies of seven such factors are presented, together with studies on components of the chromatin and transcriptome. LÄS MER

4. 28. Battling Bacterial Biofilm - antibiotic regimens targeting Grampositive pathogens in biofilm

   Författare :Anna Holmberg; Sektion III; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biofilm; antibiotic susceptibility; prosthetic joint infection; MBEC; Enterococcus faecalis; Enterococcus faecium; Propionibacterium acnes.;

   Sammanfattning : AbstractBacteria in most environments encase themselves in a hydrated matrix of polysaccharide and protein, forming organized communities called biofilms. In the biofilm bacteria are protected against hostile environments. Biofilms are important clinically because of their persistence despite host defence and their recalcitrance to antimicrobials. LÄS MER

5. 29. Familial hypercholesterolemia in Sweden : genetic and clinical studies

   Författare :Peter Benedek; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Prevention of premature disease and death from cardiovascular complications of atherosclerosis is an important goal for public health, and the early identification of individuals with increased risk is an important goal of modern medicine. Familial hypercholesterolemia (FH) is one of the most common monogenic diseases (1/250 to 1/300) where strong evidence of positive health effects of intervention has been established. LÄS MER

7. 30. Using big data to understand evolutionary patterns in Geometridae and Erebidae, the two most diverse families of Lepidoptera

   Författare :Hamid Ghanavi; Biodiversitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

   Sammanfattning : Lepidoptera (moths and butterflies) are one of the most diverse groups of organisms on earth. They have conquered all the continents apart from Antarctica. The reasons of such high diversity are still not clear. One of the first steps to study the causes of such evolutionary success is to have a clear idea of their phylogenetic relationships. LÄS MER