Sökning: "Deep sequencing"

Visar resultat 11 - 15 av 68 avhandlingar innehållade orden Deep sequencing.

1. 11. Genomics and metabolomics in the North Atlantic deep-sea sponge Geodia barretti

   Författare :Karin Steffen; Paco Cárdenas; Ulf Göransson; Anders Backlund; Susanna López-Legentil; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; demosponge; whole genome sequencing; population genetics; peptide synthesis; Farmakognosi; Pharmacognosy;

   Sammanfattning : Sponges are among the earliest diverging taxa in the animal tree of life. They are sessile, filter-feeding animals found in marine and freshwater habitats. Many species are characterized by a close, specific and consistent association with microbes, mainly Bacteria and Archaea. LÄS MER

3. 12. Intrinsic subtypes and prognostic implications in epithelial ovarian cancer

   Författare :Jenny-Maria Jönsson; Bröstcancer-genetik; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ovarian cancer; gene expression profiling; Lynch syndrome; targeted deep sequencing; chromatin remodeling; molecular subtypes; endocrine receptors; prognostic factors; tumor heterogeneity;

   Sammanfattning : Ovarian cancer is the seventh most common cancer in women globally, with approximately 240,000 new cases annually. Although a rare disease, it is the most lethal gynecologic malignancy. Unspecific symptoms result in late diagnosis and a generally poor prognosis. LÄS MER

4. 13. Ultra-deep characterization of viral quasispecies in HIV infection

   Författare :Charlotte Hedskog; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : HIV-1 has the ability to rapidly diversify and adapt to changes in its environment, such as evading the host immune response, altering cell tropism, and developing resistance to antiretroviral drugs. Minority HIV-1 variants have been shown to be of clinical significance, especially those with non-nucleoside reverse transcriptase inhibitor (NNRTI) drug resistance mutations or determinants of CXCR4 phenotype (X4-virus). LÄS MER

5. 14. Spatial mapping of bacteria and transcriptomes

   Författare :Britta Lötstedt; Joakim Lundeberg; Anders F. Andersson; Petri Auvinen; KTH; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; spatial transcriptomics; 16S sequencing; antibody-based measurements; spatiell transkriptomik; 16S-sekvensering; antikroppsbaserade mätningar; Biotechnology; Bioteknologi;

   Sammanfattning : Novel insights into biological functions and mechanisms, cell networks and evolutionary relationships are gained through development of sequencing technologies and sequencing based applications. Massively parallel sequencing has enabled analysis of big data at gene and protein expression levels, but has also characterized bacterial communities. LÄS MER

7. 15. Image and Data Analysis for Spatially Resolved Transcriptomics : Decrypting fine-scale spatial heterogeneity of tissue's molecular architecture

   Författare :Gabriele Partel; Carolina Wählby; Anna H Klemm; Mats Nilsson; Roland Eils; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; iss; image; processing; clustering; deep learning; GCN; graph;

   Sammanfattning : Our understanding of the biological complexity in multicellular organisms has progressed at tremendous pace in the last century and even more in the last decades with the advent of sequencing technologies that make it possible to interrogate the genome and transcriptome of individual cells. It is now possible to even spatially profile the transcriptomic landscape of tissue architectures to study the molecular organization of tissue heterogeneity at subcellular resolution. LÄS MER