Sökning: "Daniel Twohig"

Hittade 1 avhandling innehållade orden Daniel Twohig.

  1. 1. Apolipoprotein E and alpha-synuclein interactions, and their associations with neurodegenerative diseases

    Författare :Daniel Twohig; Henrietta M. Nielsen; Andreas Barth; Tiago Fleming Outeiro; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

    Sammanfattning : The apolipoprotein E gene (APOE) is expressed as three major isoforms, APOE ε2, ε3 and ε4 that encode the apoE2, E3 and E4 proteins, respectively. APOE ε4 is associated with an increased risk for age-related neurodegenerative diseases including Alzheimer’s disease (AD) and dementia with Lewy bodies (DLB), and increases the risk of dementia in Parkinson’s disease (PD), however, the exact molecular mechanisms underpinning the associations between APOE ε4 and neurodegeneration are still unknown. LÄS MER