Sökning: "DOPA"
Visar resultat 1 - 5 av 93 avhandlingar innehållade ordet DOPA.
1. Thiol-Ene CHemistry and Dopa-Functional Materials towards Biomedical Applications
Sammanfattning : Thiol-ene chemistry is versatile and efficient and can be used as a powerful tool in polymer synthesis. In this thesis, the concept of thiol-ene chemistry has been central, where it has been explored as a tool for the synthesis of well-defined hydrogels and dopa-functional materials towards biomedical applications; such as hydrogels, primers for adhesive fixation of bone fractures, self-healing gels, and micelles for drug-delivery. LÄS MER
2. On dopamine neurons : nerve fiber outgrowth and L-DOPA effects
Sammanfattning : Parkinson’s disease is a disorder mainly characterized by progressive degeneration of dopamine producing neurons in the substantia nigra of the midbrain. The most commonly used treatment strategy is to pharmacologically restore the lost function by the administration of the dopaminergic precursor L-DOPA. LÄS MER
3. Dysfunction in the nigrostriatal system : effects of L-DOPA and GDNF
Sammanfattning : Parkinson’s disease is a common neurodegenerative disorder caused by nigrostriatal dopamine loss, with motor deficiencies as the primary outcome. To increase the striatal dopamine content, patients are treated with 3,4-dihydroxyphenyl-l-alanine (l-DOPA). LÄS MER
4. Involvement of non-dopaminergic systems in L-DOPA-induced dyskinsia
Sammanfattning : Parkinson's disease and L-DOPA-induced dyskinesia (LID) does not merely involve the dopamine (DA) system but also include non-dopaminergic systems such as glutamate and serotonin (5-HT). An aberrant glutamate transmission at the corticostriatal synapse, has been linked to LID. LÄS MER
5. To metal, or not to metal : Diverse mechanisms of O2-activation and radical storage in the ferritin superfamily
Sammanfattning : Proteins in the Ferritin-like superfamily are characterized by a four alpha-helical structural motif. These proteins are distributed across all three kingdoms of life and perform a wide range of functions. LÄS MER