Sökning: "DNAJB6"

Hittade 4 avhandlingar innehållade ordet DNAJB6.

  1. 1. Co-assembly of proteins and lipids : From lipodiscs to amyloid aggregates

    Författare :Rebecca Frankel Willén; NanoLund: Centre for Nanoscience; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; amyloid; Aβ42; apolipoprotein A-1; aggregation; high-density lipoprotein; DNAJB6; Alzheimer s disease; protein-lipid interactions;

    Sammanfattning : Assemblies of different molecules is a prevalent phenomenon in nature, and crucial in biological life. Most of the biological assemblies are co-assembledcomposites, made up from several different components, either of thesame biomolecular type or a combination of different ones. LÄS MER

  3. 2. The Molecular Chaperone DNAJB6 - A Suppressor of Disease Related Amyloid Fibril Formation

    Författare :Cecilia Månsson; Biokemi och Strukturbiologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; DNAJ; HSP40; molecular chaperones; amyloid fibrils; Alzheimer’s disease; Huntington’s Disease; crosslinking mass spectrometry; chemical kinetics; aggregation; fibril formation;

    Sammanfattning : Several neurodegenerative diseases are caused by peptides or proteins forming amyloid fibrils such as the Aβ peptide involved in Alzheimer’s disease and the huntingtin exon-1 with a prolonged polyglutamine (polyQ) stretch involved in Huntington’s disease. The ability to form amyloid fibrils is an intrinsic feature in all proteins. LÄS MER

  4. 3. Structural studies of microbubbles and molecular chaperones using transmission electron microscopy

    Författare :Johan Härmark; Philip JB Köck; Hans Hebert; Reinhard Rachel; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Transmission electron microscopy; Contrast agent; Microbubble; Polyvinyl alcohol; Single particle analysis; Heat shock protein; Molecular chaperone; Technology and Health; Teknik och hälsa;

    Sammanfattning : Ultrasound contrast agents (CAs) are typically used in clinic for perfusion studies (blood flow through a specific region) and border delineating (differentiate borders between tissue structures) during cardiac imaging. The CAs used during ultrasound imaging usually consist of gas filled microbubbles (MBs) (diameter 1-5 μm) that are injected intravenously into the circulatory system. LÄS MER

  5. 4. Identification of novel tumor biomarkers for sensitivity to radio- and chemotherapy of lung cancer based on genomic analyses

    Författare :Hogir Salim; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Lung cancer (LC) is one of the most common human cancers and the leading cause of cancer-related deaths worldwide. Treatment of LC is by surgery if the tumor is resectable, otherwise chemo- and/or radiotherapy (CT/RT) is given. LÄS MER