Sökning: "DNA-binding mode"
Visar resultat 1 - 5 av 18 avhandlingar innehållade orden DNA-binding mode.
1. Chiral Ruthenium Dipyrodiphenazine Complexes: DNA Binding and Excited State Relaxation
Sammanfattning : Ruthenium complexes with aromatic ligands have been extensively studied due to their interesting photophysical properties, including photophysics and electron transfer upon interaction with nucleic acids. For example, the broad absorption spectrum makes them suitable as antenna molecules in photochemical reaction systems and their ability to accept or donate electrons in their excited state could have potential in opto-electronical devices. LÄS MER
2. Structural Requirements for Selective DNA Binding - Studies on Mono- and Binuclear Ruthenium Complexes
Sammanfattning : Ever since the discovery of the role of DNA as the template for protein synthesis, efforts have been made to develop DNA targeted drugs. One of the major challenges in the design of DNA binding drugs is to achieve selective binding to specific DNA sequences, which is crucial to avoid side effects. LÄS MER
3. Kinetic Recognition of Nucleic Acids - Studies on the DNA Binding Selectivity of Threading Ruthenium Complexes
Sammanfattning : Despite the great progress in our understanding of DNA during the past half-century, there are many important aspects of its chemical and biological role yet to be explored. The principles by which it selectively interacts with other molecules have attracted much interest due to the relevance for fundamental cellular processes, as well as for the development of diagnostic probes and effective pharmaceutical agents. LÄS MER
4. Targeting double-stranded DNA with locked nucleic acid-based (LNA) oligonucleotides (ON) and DNA-binding peptide conjugates
Sammanfattning : In this thesis we have studied two different types of molecules that bind to the major groove of the DNA: (i) oligonucleotides (ONs) containing locked nucleic acid (LNA) and in combination with intercalating agents (Twisted Intercalating Nucleic Acid, TINA, and Benzoquinoquinoxaline, BQQ) and (ii) peptides mimicking the leucine zipper transcription factor (GCN4 bZIP TF). Both ONs and peptides bind to the DNA double helix aiming to serve as transcription regulators of disease related genes. LÄS MER
5. Biological and Biophysical Studies on Ruthenium Complexes
Sammanfattning : Small molecules that interact with DNA through intercalation are attractive candidates for treatments against cancer and microbial infections. Octahedral ruthenium(II) polypyridyl complexes, being substitution-inert, readily synthesized and coordinately saturated, has the potential of being developed in to a new family of drugs. LÄS MER