Sökning: "DNA-Binding Proteins metabolism"

Visar resultat 1 - 5 av 7 avhandlingar innehållade orden DNA-Binding Proteins metabolism.

  1. 1. Influence of cisplatin on RNA structure in solution Escherichia coli tRNA(Ala) and human Wnt-5a 3' UTR model system studies

    Författare :Pal Papsai; Biokemi och Strukturbiologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biokemi; metabolism; Proteins; enzymology; Proteiner; enzymologi; Metabolism; Biochemistry; Naturvetenskap; Natural science; tRNA.; siRNA; probing RNA structure in solution; alanyl-tRNA synthetase; cisplatin;

    Sammanfattning : RNA molecules in the cellular environment have several important functions. In many cases, proper RNA function is intimately linked to proper three-dimensional structure of the molecule. Thus, it seems reasonable to assume that structural changes caused by external influence can strongly inhibit important cellular functions maintained by RNAs. LÄS MER

  3. 2. Gene regulation by the glucocorticoid receptor : post-DNA binding mechanisms of transcriptional activation

    Författare :Tova Almlöf; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Gene activation; Glucocorticoid receptor; Nuclear receptor; Transactivation domain; Transcription; Transcription factor; Yeast;

    Sammanfattning : The glucocorticoid receptor (GR) is a ligand-inducible transcription factor that belongs to the nuclear receptor family. The GR has important functions in cellular differentiation, development and metabolism in higher eukaryotes. LÄS MER

  4. 3. Metabolic and mitogenic transduction cascades in skeletal muscle : implications for exercise effects on glucose metabolism and gene regulation

    Författare :Mei Yu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Exercise; skeletal muscle; glucose homeostasis; insulin signal transduction; gene regulation; MAPK cascades; AMPK; MEF2-DNA binding.;

    Sammanfattning : Level of physical activity is linked to improved glucose homeostasis. The molecular signaling mechanisms by which insulin and exercise/muscle contractions lead to increased glucose transport and metabolism and gene expression have not been completely elucidated. LÄS MER

  5. 4. Structural Studies of Microbial Proteins - From Escherichia coli and Herpesviruses

    Författare :Daniel Gurmu; Heidi Erlandsen; Pär Nordlund; Arne O. Smalås; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CaiB; RibD; YhaK; SOX; ORF60; Herpesvirus; E. coli; Biochemistry; Biokemi; Biochemistry; biokemi;

    Sammanfattning : Structure biology concerns the study of the molecular structures of biological macromolecules, such as proteins, and how these relate to the function. Protein structures are also of importance in structure-based drug design. In this thesis, the work has been carried out in two different projects. LÄS MER

  7. 5. Glucocorticoid receptor function : interactions, mutants and ligand responses

    Författare :Erik Hedman; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Glucocorticoid receptor; glucocorticoids; cross-talk; GR interacting proteins; Flt3; mass spectrometry; 2D gel electrophoresis;

    Sammanfattning : The protein that is investigated in this thesis is the glucocorticoid receptor (GR), which belongs to the nuclear hormone receptor superfamily of ligand activated transcription factors. The nuclear receptors share three conserved structural domains, the N-terminal transactivating domain, the central DNA-binding domain and the C-terminal ligand-binding domain. LÄS MER