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Visar resultat 1 - 5 av 9 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Digital Electrical DNA Sensing

    Författare :Maoxiang Guo; Wouter van der Wijngaart; Fredrik Westerlund; KTH; []
    Nyckelord :DNA detection; thiol-ene-epoxy; rolling circle amplification; digital measurement; DNA stretching; microwell-array; gold nanowires; electrical measurement; specificity; limit of detection; liquid storage; disease diagnosis; lab-on-a-chip; point-of-care.;

    Sammanfattning : Molecule detection is a workhorse in life sciences and medicine, for example in cancer diagnosis and virus and bacterial detection. DNA analysis can provide vital information about the state of a host organism and its medical and health condition. LÄS MER

  3. 2. Overstretching short DNA – Single-molecule force spectroscopy studies

    Författare :Niklas Bosaeus; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; DNA stretching; mechanical properties of DNA; single molecule; optical tweezers; DNA structure;

    Sammanfattning : Structural deformation of DNA has a central role in many biological processes. It occurs, for example, during replication, transcription, and regulation of the activity of the genome. To understand these fundamental processes it is necessary to have a detailed knowledge of the mechanical properties of DNA. LÄS MER

  4. 3. Unveiling Mechanistic Details of Macromolecular Interactions: Structural Design and Molecular Modelling of DNA-Protein Systems in Their Active State

    Författare :Anna Reymer; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; molecular modelling; intercalation; homologous recombination; DNA; ruthenium II polypyridyl compounds; human Rad51;

    Sammanfattning : Molecular structure is fundamental for understanding mechanisms of molecular interactions. This applies not least to understanding biological function: every biological cell, whether bacterial or human, is an immensely complex system of thousands of molecules that exist in constant motion and interaction with each other. LÄS MER

  5. 4. Excitation and Ground-State Properties of Natural and Modified Nucleic Acid Bases

    Författare :Anders Holmén; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; ab initio; linear dichroism; DFT; transition moment; tautomerism; structure; IR; spectra; DNA bases;

    Sammanfattning : The nucleic acid bases are the carriers of genetic information in DNA and RNA. They are also the main chromophores of nucleic acids and determine their optical properties and sensitivity to UV radiation. LÄS MER

  7. 5. Smooth muscle hypertrophy and the IGF-system

    Författare :Yun Chen; David R. Clemmons; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : Insulin-like growth factor-! (IGF-I) has both metabolic and mitogenic effects on smooth muscle cells (SMCs). The effects of IGF-I are modified by a group of binding proteins (IGFBPs). The present study was devoted to smooth muscle hypertrophy and the IGF-system in smooth muscle under different conditions. LÄS MER