Sökning: "DNA replication"

Visar resultat 16 - 20 av 307 avhandlingar innehållade orden DNA replication.

  1. 16. Overstretching short DNA – Single-molecule force spectroscopy studies

    Författare :Niklas Bosaeus; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; DNA stretching; mechanical properties of DNA; single molecule; optical tweezers; DNA structure;

    Sammanfattning : Structural deformation of DNA has a central role in many biological processes. It occurs, for example, during replication, transcription, and regulation of the activity of the genome. To understand these fundamental processes it is necessary to have a detailed knowledge of the mechanical properties of DNA. LÄS MER

  3. 17. Replication Fork Stability in Mammalian Cells

    Författare :Ingegerd Elvers; Thomas Helleday; Jan H. J. Hoeijmakers; Stockholms universitet; []
    Nyckelord :replication fork progression; replication fork stability; re-priming; DNA damage signalling; NATURAL SCIENCES; NATURVETENSKAP; molekylärgenetik; Molecular Genetics;

    Sammanfattning : Maintaining replication fork integrity is vital to preserve genomic stability and avoid cancer. Physical DNA damage and altered nucleotide or protein pools represent replication obstacles, generating replicative stress. Numerous cellular responses have evolved to ensure faithful DNA replication despite such challenges. LÄS MER

  4. 18. Statistical Modelling of Cell Cycle Dynamics Analysis and Interpretation of BrdUrd DNA FCM-Derived Data

    Författare :Sara Larsson Lönn; Matematisk statistik; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; G2 phase duration; DNA replication; flow cytometry; Natural science; Naturvetenskap; S phase duration; DNA distribution; branching processes; cell cycle kinetics;

    Sammanfattning : It it of great importance to increase the knowledge of various cell cycle kinetic parameters and the objective of this thesis is to use stochastic models to interpret Bromodeoxyuridine (BrdUrd) DNA Flow Cytometry (FCM) derived data in order to estimate such parameters. The cell cycle is the process of growth and division that is essential for an organism to increase in size. LÄS MER

  5. 19. Molecular mechanisms of mitochondrial DNA replication

    Författare :Teresa Holmlund; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Mitochondria; mtDNA; replication; helicase; TWINKLE; POLgamma; POLgammaB; mtSSB; adPEO;

    Sammanfattning : Mitochondria are the energy producing organelles of eukaryotic cells. The organelle has its own genome, the mitochondrial DNA (mtDNA) that encodes 13 subunits of the respiratory chain (RC) complexes, two rRNAs and 22 tRNAs. LÄS MER

  7. 20. Activity of tumor-antigens in polyomavirus replication

    Författare :Hongyun Li; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; Tumor-Antigens; DNA Replication; Cell-cycle; Phosphorylation; J-domain; Biokemi; Biochemistry; Biokemi; Medical Virology; medicinsk virologi;

    Sammanfattning : Polyomavirus replication needs an active cell environment, and the viral DNA replication is cell cycle regulated. Tumor antigens (T-antigens) of mouse polyomavirus, especially large T-antigen, are necessary for the replication. LÄS MER