Sökning: "DNA repair"

Visar resultat 16 - 20 av 333 avhandlingar innehållade orden DNA repair.

  1. 16. Primary Sjögren's Syndrome: Studies of DNA damage responses and autoantibodies

    Författare :Gunnel Henriksson; Malmö Klinisk mikrobiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; autoantibodies; 18 ; t 14; cell cycle; p53; DNA-PK; DNA-binding protein; hypermutation; Sjögren s syndrome; DNA damage; anti-CD4 antibodies; Microbiology; bacteriology; virology; mycology; Mikrobiologi; bakteriologi; virologi; mykologi;

    Sammanfattning : Primary Sjögren’s syndrome (SS) is a chronic autoimmune disease of unknown etiology. The disease primarily involves lachrymal and salivary glands, leading to dryness of the eyes and mouth, but a wide spectrum of exocrine and non-exocrine disease manifestations may be seen. LÄS MER

  3. 17. Structure of eukaryotic DNA polymerase epsilon and lesion bypass capability

    Författare :Nasim Sabouri; Erik Johansson; Lars Thelander; Ola Hammarsten; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; DNA polymerase epsilon; DNA replication; Okazaki fragment; Translesion synthesis; DNA lesion; dNTP; Biochemistry; Biokemi;

    Sammanfattning : To transfer the information in the genome from mother cell to daughter cell, the DNA replication must be carried out only once and with very high fidelity prior to every cell division. In yeast there are several different DNA polymerases involved in DNA replication and/or DNA repair. LÄS MER

  4. 18. DNA repair and the p53 pathway in ischemic and traumatic brain injury

    Författare :Gregor Tomasevic; Neurokirurgi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neuronal death; DNA repair; knock-out mice; XPA; p53; mRNA; hippocampus; preconditioning; hypothermia; trauma; Brain; ischemia; neurobehavior; Neurology; neuropsychology; neurophysiology; Neurologi; neuropsykologi; neurofysiologi;

    Sammanfattning : Ischemic and traumatic brain damage are major causes of disability and death. While much effort has been spent to develop pharmacological treatments for these conditions, no neuroprotective drugs are in clinical use. LÄS MER

  5. 19. Post-translational modifications in DNA base excision repair : The roles of CK2 and PARP-1

    Författare :Cecilia Ström; Thomas Helleday; Hans Krokan; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; base excision repair; single-strand break repair; PARP-1; CK2; XRCC1; mammalian cells; Cell and molecular biology; Cell- och molekylärbiologi; molekylärgenetik; Molecular Genetics;

    Sammanfattning : Base lesions and DNA single-strand breaks (SSBs) are very common types of DNA damage. The base excision repair (BER) and single-strand break repair (SSBR) machineries both require a succession of enzymatic events in order to remove these types of endogenous lesions and to restore the DNA. LÄS MER

  7. 20. Mismatch repair deficiency in colorectal cancer : prognosis and prediction for basic treatment strategies

    Författare :Ioannis Gkekas; Jan Novotny; Karin Strigård; Richard Palmqvist; Ulf Gunnarsson; Christian Sturesson; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; colorectal cancer; defective mismatch repair; prognosis and prediction; Oncology; onkologi;

    Sammanfattning : Colorectal cancer (CRC) remains a significant healthcare problem worldwide, being the third most common cancer and the fourth most frequent cause of cancer death. Environmental and dietary factors such as alcohol abuse, cigarette smoking, and genetic predisposition seem to constitute the main aetiologies. LÄS MER