Sökning: "DNA repair"
Visar resultat 11 - 15 av 333 avhandlingar innehållade orden DNA repair.
11. The role of chromatin in the induction and repair of DNA damage
Sammanfattning : The role of chromatin in the induction and repair of DNA damage has a dual nature.The constituent proteins of chromatin protect the DNA against the induction of DNAdamage, while at the same time they reduce the accessibility of DNA to repair enzymes. LÄS MER
12. Chemically Induced DNA Damage in Extended-term Cultures of Human Lymphocytes
Sammanfattning : Generation of DNA damage is regarded to be an important initial event in the development cancer. Consequently, a battery of tests have been developed to detect different types of genotoxic effects in order to be able to predict the potential genotoxicity and mutagenicity of chemicals, including both pharmaceutical drugs and various types of environmental and occupational agents, as well as dietary factors. LÄS MER
13. Repair of DNA double-stranded breaks in human cells
Sammanfattning : DNA is continuously subjected to degradation. Therefore, our cells need to constantly repair its DNA to prevent mutations and in the long run cancer. In mammalian cells, when DNA is broken right off, a double-stranded break (DSB) is produced, and the ends are ligated by a process called non-homologous end-joining (NHEJ). LÄS MER
14. Interstrand Crosslinks - Induction and repair
Sammanfattning : DNA crosslinking agents exhibit a variety of DNA lesions, such as monoadducts, DNA-DNA interstrand or intrastrand crosslinks or DNA-protein crosslinks. Agents that produce interstrand crosslinks (ICLs) exist naturally and are widely used in chemotherapy. Therefore, it is important to understand how the lesions induced by these agents are repaired. LÄS MER
15. Replication Dynamics in the DNA Damage Response
Sammanfattning : Faithful DNA replication is essential and the induction of replication stress may have profound effects on genomic integrity. This is demonstrated by the formation of DNA double strand breaks (DSBs), considered to be the most toxic DNA lesions, at stalled replication forks. LÄS MER