Sökning: "DNA ligand"
Visar resultat 1 - 5 av 175 avhandlingar innehållade orden DNA ligand.
1. The circular dichroism of DNA-ligand systems
Sammanfattning : .... LÄS MER
2. DNA-ligand interactions studied by optical spectroscopy
Sammanfattning : .... LÄS MER
3. Concatemerization of Synthetic Oligonucleotides, Assembly on Surface and Ligand Interactions
Sammanfattning : DNA nanotechnology has become an important research field because of its advantages in high predictability and accuracy of base-paring recognition. DNA concatemer, one of the simplest DNA constructs in shape, have been found as efficient signal amplifiers in several biosensors for different applications. LÄS MER
4. Unveiling biomacromolecule interactions-NMR and optical spectroscopy studies on ligand binding to DNA and lysozyme
Sammanfattning : Studies on intercalation of bulky binuclear ruthenium compounds into DNA have attracted attention due to their slow dissociation rate and sequence selectivity. Previous results showed that dumb-bell shaped molecules of the type [μ-(bidppz)(L)4Ru2]4+, L=phenanthroline or bipyridine, bind rapidly on the surface of DNA prior to intercalation. LÄS MER
5. Redefining the essential molecular aspects that drive interactions between small molecules and G-quadruplex DNA
Sammanfattning : G-Quadruplex (G4) structures are secondary nucleic acid structures located in guanine-rich regions of DNA and RNA sequences, involved in gene regulation and cellular maintenance. Efforts to target G4s in a therapeutic setting are scarce, mainly due to vague details about the binding interactions between the ligands and the G4 structure combined with the lack of emphasis on drug-like properties early in the ligand development process. LÄS MER