Sökning: "DNA lesion"

Visar resultat 6 - 10 av 42 avhandlingar innehållade orden DNA lesion.

  1. 6. Inflammation in atherosclerosis

    Författare :Ken Jatta; Allan Sirsjö; Michael D. Menger; Örebro universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Atherosclerosis; chemokine; cytokine; inflammation; Lipopolysacchride; Carotid lesion; interleukin; viperin Cig5; smooth muscle cells; Cardiovascular medicine; Kardiovaskulär medicin; MEDICINE; MEDICIN; Biomedicin; Biomedicine;

    Sammanfattning : Consequences of atherosclerosis may result in a number of diseases of the cardiovascular system that represent serious health problems and major causes of morbidity and mortality worldwide. Although it is initially considered as disease of fibro-lipid and thrombus deposition in the arterial wall, it also involves an ongoing inflammatory response. LÄS MER

  3. 7. Mechanisms controlling DNA damage survival and mutation rates in budding yeast

    Författare :Jörgen Wiberg; Andrei Chabes; Per Sunnerhagen; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; dNTPs; ribonucleotide reductase; translesion synthesis; TLS polymerases; medicinsk biokemi; Medical Biochemistry;

    Sammanfattning : All living organisms are made of cells, within which genetic information is stored on long strands of deoxyribonucleic acid (DNA). The DNA encodes thousands of different genes and provides the blueprint for all of the structures and activities occurring within the cell. LÄS MER

  4. 8. Interplay between DNA repair pathways at replication forks in mammalian cells

    Författare :Fredrik Johansson; Dag Jenssen; Klaus Erixon; Harry Vrieling; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Toxicology; Toxikologi;

    Sammanfattning : Cellular DNA is continuously being damaged by various agents of both endogenous and exogenous origin including a wide range of chemical compounds, UV-light and ionizing radiation. In order to remove lesions from the DNA and maintain genomic stability, different repair processes have evolved. LÄS MER

  5. 9. DNA fragmentation in cultured cells exposed to high linear energy transfer radiation

    Författare :Erik Höglund; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oncology; Onkologi; Oncology; Onkologi; Biomedical Radiation Science; biomedicinsk strålningsvetenskap;

    Sammanfattning : The DNA double-strand break (DSB) is a critical lesion which, if not completely restored, can have serious biological consequences. The relative biological effectiveness (RBE) of many severe end-points are closely related to radiation quality, with increased effectiveness at elevated ionization density. LÄS MER

  7. 10. Studies of cohesin functions in the yeast and human DNA damage response

    Författare :Elin Enervald; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Maintaining genome stability is critical to cell survival and normal cell growth and most human cancers display some form of genome instability. Genome instability is caused by multiple reasons and the ability to properly recognize, signal and subsequently repair DNA damages is crucial. LÄS MER