Sökning: "DNA lesion"

Visar resultat 1 - 5 av 42 avhandlingar innehållade orden DNA lesion.

  1. 1. Structure of eukaryotic DNA polymerase epsilon and lesion bypass capability

    Författare :Nasim Sabouri; Erik Johansson; Lars Thelander; Ola Hammarsten; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; DNA polymerase epsilon; DNA replication; Okazaki fragment; Translesion synthesis; DNA lesion; dNTP; Biochemistry; Biokemi;

    Sammanfattning : To transfer the information in the genome from mother cell to daughter cell, the DNA replication must be carried out only once and with very high fidelity prior to every cell division. In yeast there are several different DNA polymerases involved in DNA replication and/or DNA repair. LÄS MER

  3. 2. Chemically Induced DNA Damage in Extended-term Cultures of Human Lymphocytes

    Författare :Maria Andersson; Björn Hellman; Leif Busk; Uppsala universitet; []
    Nyckelord :Toxicology; Comet assay; DNA-damaging agents; DNA repair; Extended-term Cultures of Human Lymphocytes; Genotoxicity; Induced DNA damage; In vitro; Mouse Lymphoma Cells; Primary Cell Cultures; Reactive Oxygen Species; Toxikologi;

    Sammanfattning : Generation of DNA damage is regarded to be an important initial event in the development cancer. Consequently, a battery of tests have been developed to detect different types of genotoxic effects in order to be able to predict the potential genotoxicity and mutagenicity of chemicals, including both pharmaceutical drugs and various types of environmental and occupational agents, as well as dietary factors. LÄS MER

  4. 3. UV-induced DNA damage in humans

    Författare :Vladimir J Bykov; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :32P-HPLC; photoproducts; DNA repair; solar simulated radiation; erythema; sunscreens; humans;

    Sammanfattning : Ultraviolet radiation is considered to be the most harmful part of solar energy affecting man. The depletion of the ozone layer around the Earth increases the total exposure to UV-light. The incidence of skin cancer in man has been shown to be associated with exposure to solar radiation, especially to UV-light. LÄS MER

  5. 4. Quantum Chemical Studies of Protein-Bound Chromophores, UV-Light Induced DNA Damages, and Lignin Formation

    Författare :Bo Durbeej; Leif Eriksson; Tim Clark; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Quantum chemistry; quantum chemistry; calculations; density functional theory; excited states; photochemistry; chromophores; absorption spectra; bathochromic shift; isomerization; UV radiation; DNA damages; cycloaddition reactions; photoenzymic repair; electron transfer; lignin; polymerization; phenoxy radicals; dilignols; Kvantkemi; Quantum chemistry; Kvantkemi;

    Sammanfattning : Quantum chemical methods have been used to provide a better understanding of the photochemistry of astaxanthin and phytochromobilin; the photoenzymic repair of UV-light induced DNA damages; and the formation of lignin. The carotenoid astaxanthin (AXT) is responsible for the colouration of lobster shell. LÄS MER

  7. 5. Studies on DNA adducts and carcinogenesis with 2-nitrofluorene as a model substance

    Författare :Xian-Shu Cui; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :2-nitrofluorene; carcinogens; DNA adducts; preneoplastic lesion; tumor;

    Sammanfattning : A number of carcinogens or their electrophilic intermediates are able to bind covalently to DNA, forming DNA adducts. DNA adducts may cause gene mutations if they are misrepaired or remain unrepaired before DNA replication occurs. DNA adduct formation is believed to be the initial step of chemical carcinogenesis. LÄS MER