Sökning: "DNA integrity"
Visar resultat 1 - 5 av 101 avhandlingar innehållade orden DNA integrity.
1. The consequences of DNA lesions for mitochondrial DNA maintenance
Sammanfattning : Eukaryotic cells have their own energy-producing organelles called mitochondria. The energy is stored in the adenosine triphosphate (ATP) molecule and is produced via the oxidative phosphorylation process inside the mitochondria. Thirteen of the essential proteins required for this process are encoded on the mitochondrial DNA (mtDNA). LÄS MER
2. Stability of bacterial DNA in relation to microbial detection in teeth
Sammanfattning : The fate of DNA from dead cells is an important issue when interpreting results from root canal infections analysed by the PCR technique. DNA from dead bacterial cells is known to be detectable long time after cell death and its stability is dependent on many different factors. LÄS MER
3. Ribonucleotides in DNA - Application in genome-wide DNA polymerase tracking and physiological role in eukaryotes
Sammanfattning : The genetic code in the eukaryotic cell is stored in the form of DNA, which is more resistant to hydrolysis than RNA. Replication fidelity and DNA repair mechanisms are in place to ensure genomic integrity to preserve the information encoded. LÄS MER
4. Controlling DNA compaction and the interaction with model biomembranes
Sammanfattning : The studies described in this thesis forms part of a larger collaborative project, Neonuclei, with the objective to design a module for packaging the negatively charged DNA into a ”neonucleus” with transcription competence. There are many applications that require control of DNA compaction, i.e. packaging or condensation. LÄS MER
5. Maintaining DNA replication fork integrity
Sammanfattning : .... LÄS MER