Sökning: "DNA dye"
Visar resultat 1 - 5 av 34 avhandlingar innehållade orden DNA dye.
1. Sensitive Forensic DNA Analysis : Application of Pyrosequencing and Real-time PCR Quantification
Sammanfattning : The field of forensic genetics is growing fast and the development and optimisation of more sensitive, faster and more discriminating forensic DNA analysis methods is highly important. In this thesis, an evaluation of the use of novel DNA technologies and the development of specific applications for use in forensic casework investigations are presented. LÄS MER
2. Fluorimetric Bioprobe Based on DNA-dye Intercalation - Application in Enviromental and Clinical Monitoring
Sammanfattning : Nucleic acids have many unique structural features that offer reliable means of recognizing and monitoring many compounds of medical or environmental importance. In recent years, there has been an enormous increase in the use of nucleic acids as a tool to determine the chemical compounds of environmental and clinical interest and the major research activities in these areas have been directed towards the design of sequence-selective biosensors based on hybridization. LÄS MER
3. Effects of Antioxidants and Pro-oxidants on Oxidative Stress and DNA Damage using the Comet Assay : Studies on Blood Cells from Type 2 Diabetes Subjects and Mouse Lymphoma Cells
Sammanfattning : Diet and oral supplements comprise two distinct sources of antioxidants known to prevent oxidative stress. Beneficial effects from antioxidants have been seen for patients at risk for type 2 diabetes.The aim of this thesis was to evaluate the positive effects of antioxidants against oxidative stress and DNA damage in type 2 diabetes subjects. LÄS MER
4. Recognition and Visualization of Nucleic Acids
Sammanfattning : The work presented in this Thesis focuses on the interaction between nucleic acids and small molecules, as well as binding or incorporation of reporter chromophores into nucleic acids. The results could help in studying and understanding processes that are fundamental to describe mechanisms behind a genetic disorder. LÄS MER
5. Detection of Biomolecules: Syntheses and Studies of Minor Groove Binding Unsymmetrical Cyanine Dyes and Chromogenic Enzyme Substrates
Sammanfattning : Visualisation or detection of biomolecules is usually achieved by the use of fluorescent or highly coloured chromophores. The work presented in this thesis deals with the development of new chromogenic substrates for the detection of enzyme activity, and new DNA-binding fluorescent dyes for staining of DNA. LÄS MER