Sökning: "DNA detection methods"

Visar resultat 46 - 50 av 200 avhandlingar innehållade orden DNA detection methods.

  1. 46. High-performance liquid chromatography for analysis of 32P-postlabeled DNA adducts

    Författare :Magnus Zeisig; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :DNA adducts; 32P-postlabeling; HPLC; method development;

    Sammanfattning : The formation of DNA adducts, i.e. the covalent binding of chemicals and chemical groups to DNA, is believed to be an important step in chemical carciogenesis. DNA adducts are usually formed at very low levels which requires very sensitive methods to analyze them. LÄS MER

  3. 47. Statistical methods for the detection, analyses and integration of biomarkers in the human genome and transcriptome

    Författare :Chen Suo; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Most human diseases have been shown to have a genetic basis that is linked to regulation of gene expression at the transcriptional or post-transcriptional level. In the central dogma of biology, deoxyribonucleic acid (DNA) is transcribed to messenger ribonucleic acid (mRNA), and then translated into proteins; dysfunction in any of these processes may contribute to the development of disease. LÄS MER

  4. 48. Retroviral long Terminal Repeats; Structure, Detection and Phylogeny

    Författare :Farid Benachenhou; Jonas Blomberg; Göran Sperber; Aris Katzourakis; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Retrovirus; long terminal repeats; hidden Markov models; phylogeny; alignment; conserved motif; stem-loop; Clinical virology; Klinisk virologi; Klinisk virologi; Clinical Virology;

    Sammanfattning : Long terminal repeats (LTRs) are non-coding repeats flanking the protein-coding genes of LTR retrotransposons. The variability of LTRs poses a challenge in studying them. Hidden Markov models (HMMs), probabilistic models widely used in pattern recognition, are useful in dealing with this variability. LÄS MER

  5. 49. Polymer microfluidic systems for samplepreparation for bacterial detection

    Författare :Mikael Hillmering; Wouter van der Wijngaart; Tommy Haraldsson; Klas Hjort; KTH; []
    Nyckelord :;

    Sammanfattning : Sepsis, caused by blood stream infection, is a very serious health condition thatrequires immediate treatment using antibiotics to increase the chances for patientsurvival. A high prevalence of antibiotic resistance among infected patients requiresstrong and toxic antibiotics to ensure effective treatment. LÄS MER

  7. 50. Analysis of DNA adducts of some low molecular weight aldehydes : methods development and application in human biomonitoring

    Författare :Jia-Long Fang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Malondialdehyde (MA), acetaldehyde (Aa) and methylglyoxal (MG) are ubiquitously present in the environment and endogenously formed in animals and humans. They have been shown to be genotoxic and to readily react with DNA to form DNA adducts under physiological conditions. LÄS MER