Sökning: "DNA detection methods"

Visar resultat 31 - 35 av 200 avhandlingar innehållade orden DNA detection methods.

  1. 31. Mosaic loss of chromosome Y : methods for detection and consequences for affected leukocytes and men

    Författare :Marcus Danielsson; Lars A. Forsberg; Ståhl Patrik; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; mosaic loss of chromosome Y; mLOY; somatic mosaicism; Medicinsk genetik; Medical Genetics;

    Sammanfattning : It has been known for centuries that men live shorter lives than women, but until recently, the biological mechanisms driving this sex bias has been poorly understood. Mosaic loss of chromosome Y (mLOY) refers to chromosome Y aneuploidy, a male specific and the most common somatic mutation in human blood cells. LÄS MER

  3. 32. Improved Techniques for High-Throughput Molecular Diagnostics

    Författare :Mario Curcio; KTH; []
    Nyckelord :DNA; Molecular Diagnostics;

    Sammanfattning : The amount of information derived from sequencing the humangenome is leading to an exponential increase in the rate atwhich genes and genetic disorders are mapped and characterized.As a consequence, the demand for genetic testing is alsodramatically increasing. LÄS MER

  4. 33. Long-term survival and prognostic factors in endometrial cancer - a populationbased cohort study

    Författare :Teresia Svanvik; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Endometrial cancer; relative survival; DNA ploidy; s-phase fraction; p53; socioeconomic inequality; early detection;

    Sammanfattning : Aims: The over-all aims of this thesis were to evaluate the associations between prognostic factors and excess mortality rate, between socioeconomic and immigrant status and incidence rate, in endometrioid (EEC) and non-endometrioid (NEC) endometrial carcinoma. Material and methods: Study I-III were retrospective population-based cohort studies including women resident in a defined geographical area, with endometrial carcinoma. LÄS MER

  5. 34. DNA Tools and Microfluidic Systems for Molecular Analysis

    Författare :Jonas Jarvius; Ulf Landegren; Mats Nilsson; P Luke Lee; Uppsala universitet; []
    Nyckelord :Molecular medicine; Proximity ligation; Microfluidics; Single molecule detection; Microarray; Bonding; Molekylärmedicin;

    Sammanfattning : Improved methods are needed to interrogate the genome and the proteome. Methods with high selectivity, wide dynamic range, and excellent precision, capable of simultaneously analyzing many biomolecules are required to decipher cellular function. This thesis describes a molecular and microfluidic toolbox designed with those criteria in mind. LÄS MER

  7. 35. Improved human papillomavirus DNA typing methods and biology of cervival cancer

    Författare :Biying Zheng; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Cervical cancer; human papillomavirus; Pyrosequencing; chemokine receptors; adenoassociated virus; biomarkers; and cell cycle checkpoint.;

    Sammanfattning : Cervical cancer is the second most common cancer among women worldwide. Persistent HPV has been identified as a main risk factor in cervical cancer development. Oncoproteins E6 and E7 of highrisk HPV interact with cellular proteins, subverting cell cycle checkpoint, inducing carcinogenesis. LÄS MER