Sökning: "DNA Microarrays"

Visar resultat 11 - 15 av 68 avhandlingar innehållade orden DNA Microarrays.

  1. 11. Metabolic Engineering of Central Carbon Metabolism in Saccharomyces cerevisiae The contribution of systems biology to physiological studies

    Författare :Marta Papini; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; fermentation technology; Metabolic engineering; RNA-sequencing; Saccharomyces cerevisiae; DNA microarrays; 13Cbased flux analysis; system biology; Scheffersomyces stipitis;

    Sammanfattning : Saccharomyces cerevisiae is one of the most well characterized yeast of large industrial interest due to several attractivefeatures such as its capability to efficiently convert glucose into ethanol and carbon dioxide at high flux, its amenabilityto genetic modification and the presence of extensive knowledge databases. For these reasons, it is often considered asuitable cell factory for the production of different classes of compounds. LÄS MER

  3. 12. Vitreoscilla Haemoglobin. Genetic Fusions and Metabolic Characterisation

    Författare :Viktoria Roos; Tillämpad biokemi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; Metabolism; Biokemi; metabolism; osmotic stress; transcript profiling; DNA microarrays; random elongation mutagenesis; directed evolution; mRNA structure; Vitreoscilla haemoglobin VHb ; Escherichia coli; salt stress.;

    Sammanfattning : Vitreoscilla is an obligate aerobic bacterium living in oxygen-poor environments such as stagnant ponds and decaying vegetable matter. Vitreoscilla expresses a homodimeric haemoglobin (VHb) when subjected to oxygen-limited conditions. LÄS MER

  4. 13. Bioinformatic approaches to gene expression in leukemia. Networks and deconvolution

    Författare :Linnea Järvstråt; Hematogenomics; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; bioinformatics; acute myeloid leukemia; networks; deconvolution; microarrays; ChIP-seq; DEK; WT1;

    Sammanfattning : The aim of this thesis is develop methods to extract information from high-dimensionality data and to apply them in looking at gene-gene and gene-protein interactions in Acute Myeloid Leukemia (AML). The in silico methods developed can be used with data from other systems. LÄS MER

  5. 14. Integration of functional genomics and data mining methodologies in the study of bipolar disorder and schizophrenia

    Författare :Marianthi Logotheti; Nikolaos Venizelos; Fragiskos Kolisis; Nikos Stefanis; Örebro universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Bipolar Disorder; Schizophrenia; Fibroblasts; DNA Microarrays; Machine Learning; Functional Analysis; Gene Expression; Transcriptomics;

    Sammanfattning : Bipolar disorder and schizophrenia are two severe psychiatric disorders characterized by a complex genetic basis, coupled to the influence of environmental factors. In this thesis, functional genomic analysis tools were used for the study of the underlying pathophysiology of these disorders, focusing on gene expression and function on a global scale with the application of high-throughput methods. LÄS MER

  7. 15. Technological Advancements in Affinity Proteomics : From planar antibody microarrays towards a solution-based platform

    Författare :Mattias Brofelth; Institutionen för immunteknologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Affinity proteomics; Antibody microarrays; scFv; Biomarkers; MIAS;

    Sammanfattning : Abstract: Proteomics has the potential to deliver disease-associated biomarkers that could provide diagnostic, prognostic and predictive information to enable precision medicine. Affinity proteomics, most commonly based on antibodies and their ability to specifically capture target proteins, has emerged has a valuable tool in biomarker discovery. LÄS MER