Sökning: "DNA Ligases"

Visar resultat 1 - 5 av 12 avhandlingar innehållade orden DNA Ligases.

  1. 1. Diversity of thermostable DNA enzymes from Icelandic hot springs

    Författare :Sigridur Hjorleifsdottir; Bioteknik; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; thermophiles; microbial diversity; SSU rRNA; Thermus; hot springs; Biotechnology; Bioteknik; Biochemistry; enzymologi; Proteiner; enzymology; metabolism; Proteins; DNA enzymes; Biokemi;

    Sammanfattning : The diversities of bacteria as well as thermostable DNA enzymes in Icelandic hot springs were studied using different techniques. First of all the bacterial diversity of different microbial mats as well as sediment samples was described by using both molecular methods and cultivation methods. LÄS MER

  3. 2. Characterization of Amino Acid tRNA Ligases using the Analytical Ultracentrifuge

    Författare :Lars Lundvik; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; amino acid tRNA ligase; analytical ultracentrifugation;

    Sammanfattning : ABSTRACT. Quaternary structures of amino acid tRNA ligases/synthetases (aaRS) in the native as well as in denatured forms were examined by molecular weight determinations (paper I-IV). Analytical ultracentrifugation, gel electrophoresis, gel chromatography were used in these investigations. LÄS MER

  4. 3. The role of the cohesin loader in genome stability : a journey from yeast to human

    Författare :Fosco Giordano; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Structural Maintenance of Chromosome (SMC) complexes, as their name suggests, have a central role in maintaining the higher structure of genomes, from bacteria to human, and in doing so protecting their integrity. Cohesin, one of three SMC complexes, is required to hold sister chromatids together until anaphase, and for homologous recombination-based DNA repair. LÄS MER

  5. 4. From oncogenic replication stress to drug resistance : F-box proteins as signalling hubs in cancer

    Författare :Andrä Brunner; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Cancer arises from cells that acquire genetic and epigenetic changes during the course of a, sometimes decades-long, somatic evolutionary process. These changes result in deregulation of a multitude of cellular processes leading to novel capabilities, often referred to as hallmarks of cancer, and a strong selective advantage for these cells albeit at a dramatic cost to the organism as a whole. LÄS MER

  7. 5. Studying the cell cycle using systems biology and high content characterization of the ubiquitin proteasome system

    Författare :Johan Boström; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The cell cycle is the process through which our cells grow and divide in a carefully orchestrated and controlled manner. An uncontrolled cell cycle is a basic hallmark of cancer, in which excessive cell growth leads to adverse effects on the tissue- and organ-level. LÄS MER