Sökning: "DMPC"

Visar resultat 1 - 5 av 11 avhandlingar innehållade ordet DMPC.

  1. 1. Molecular Dynamics Investigations of Structure and Dynamics of Lipid Bilayers and Associated Anesthetics

    Författare :Carl-Johan Högberg; Alexander Lyubartsev; Lennart Nilsson; Stockholms universitet; []
    Nyckelord :DMPC; Molecular dynamics simulations; Anesthetics; Lidocaine; Physical Chemistry; fysikalisk kemi;

    Sammanfattning : Detailed understanding of lipid bilayers are of tremendous importance due to their role in many biological processes. This Thesis focuses on structural and dynamical properties of lipid bilayers and their interactions with locally acting anesthetics, studied by Molecular Dynamics simulations. LÄS MER

  3. 2. Biological membrane interfaces involved in diseases : a biophysical study

    Författare :Fredrick Lindström; Gerhard Gröbner; Dick Sandström; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Solid-state NMR; DSC; Amyloid-beta peptide; Nociceptin; DMPC; DMPG; DDAB; peptide-lipid interaction; branched-chain fatty acid.; Biophysical chemistry; Biofysikalisk kemi;

    Sammanfattning : Interactions between peptides and biological lipid membranes play a crucial role in many cellular processes such as in the mechanism behind Alzheimer’s disease where amyloid-beta peptide (Abeta)is thought to be a key component. The initial step of binding between a surface active peptide and its target membrane or membrane receptor can involve a non specific electrostatic association where positively charged amino acid residues and a negatively charged membrane surface interact. LÄS MER

  4. 3. Foreign molecules in biomembranes : Molecular effects on intact stratum corneum and model lipid systems

    Författare :Quoc Dat Pham; Fysikalisk kemi; []
    Nyckelord :stratum corneum; lipid; keratin filament; protein; DMPC; penetration enhancer; osmolyte; solvent; monoterpene; fatty acid; hydration; molecular mobility; fluidity; permeability; PT ssNMR; diffusion cell;

    Sammanfattning : This thesis mainly explores how the molecular mobility of lipid and protein components in the outermost layer of the skin, the stratum corneum (SC), varies with different conditions and upon adding foreign compounds. These studies require methods that makes it possible to detect and characterize the minor amount of fluid components in the highly ordered solid SC sample with resolved molecular information. LÄS MER

  5. 4. Structural studies of bio-molecules and lipid assemblies using polarized light spectroscopy

    Författare :Maxim Kogan; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; linear dichroism; lipid membrane; spectroscopy; ruthenium complex; phospholipids; DNA breathing;

    Sammanfattning : The focus of the research presented in this thesis is structural studies of biological macromolecules using Linear Dichroism (LD) spectroscopy. The first part covers the flow alignment and structure of DMPC/DHPC phospholipid aggregates. LÄS MER

  7. 5. Biophysical studies of membrane associated biomolecular interactions

    Författare :Weihua Ye; Arnold Maliniak; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : Membrane associated interactions play important roles in various biological processes. The aim of this thesis is to study two types of membrane associated interactions by using biophysical methods, particularly NMR. First, the interaction of a targeting peptide and a receptor attached to membrane has been studied. LÄS MER