Sökning: "DIFFERENTIATION MARKER"

Visar resultat 1 - 5 av 194 avhandlingar innehållade orden DIFFERENTIATION MARKER.

  1. 1. Hypoxia and differentiation in human neuroblastoma cells

    Författare :Helén Nilsson; Institutionen för translationell medicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ontogeny; embryology human ; Utvecklingsbiologi; teratologi; embryologi människa ; teratology; cytogenetik; Development biology; cytogenetics; Genetik; Genetics; Medicin människa och djur ; HIF; Medicine human and vertebrates ; MYCN; Hypoxia; differentiation; Neuroblastoma;

    Sammanfattning : The childhood tumour neuroblastoma is derived from immature cells of the sympathetic nervous system, which have become arrested at different maturation stages. Neuroblastoma is a malignancy with a high degree of heterogeneity, and there is a correlation between a poor differentiation status and a more aggressive phenotype. LÄS MER

  3. 2. A genomic approach to smooth muscle differentiation and diversity

    Författare :Sven Nelander; Göteborgs universitet; []
    Nyckelord :Keywords: smooth muscle; phenotype; transcriptional regulation; differentiation; transcriptome; microarray; computational prediction; co-expression network; regulatory sequence analysis; gene module; gene battery;

    Sammanfattning : Smooth muscle cells (SMCs) are a broad class of contractile cells that are found in a number of organs systems, including the vasculature, the urogenital system, the bronchi and the gastrointestinal tract. The two main functions exerted by SMCs are to provide contractile force and to synthesize structural components of the extracellular matrix. LÄS MER

  4. 3. Hypoxia-Inducible Factors in Tumor Cell Differentiation and Tumor Vascularization

    Författare :Alexander Pietras; Institutionen för translationell medicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; HIF-2alpha; cancer; notch; angiogenesis; tumor-initiating cells; hypoxia; neuroblastoma; differentiation;

    Sammanfattning : Mammalian cells, including tumor cells, adapt to hypoxia via stabilization of two transcription factors - Hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha. Among other consequences, hypoxia is a main driving force behind angiogenesis. LÄS MER

  5. 4. Functional analysis of Ipf1/Pdx1, MFng and Id during pancreatic growth and differentiation

    Författare :Per Svensson; Helena Edlund; Henrik Semb; Umeå universitet; []
    Nyckelord :pancreas; proliferation; differentiation; signalling; expression; FgfR2IIIb; ErbB3; spondin1; MFng; Id; molekylär medicin genetik och patologi ; molecular medicine  genetics and pathology ;

    Sammanfattning : The pancreas is an endodermally derived organ consisting of three major cell lineages. The endocrine cells, organised into the Islets of Langerhans, regulate blood glucose homeostasis by producing and secreting hormones such as glucagon and insulin into the bloodstream. LÄS MER

  7. 5. Expression of Tissue Antigens in Human Pluripotent Stem Cells and Alterations During Differentiation : Potential application in regenerative medicine for treatment of terminal cell and organ failure

    Författare :Karin Säljö; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pluripotent stem cells; Differentiation; Histo-blood group antigens; HLA; Tissue antigens; Sialyl-lactotetra; Cell surface antigens; Transplantation; Regenerative medicine;

    Sammanfattning : The major limiting factor in the treatment of patients with end-stage organ failure is the insufficient number of human organs available for transplantation. An unlimited access to human cells, tissues and organs would also open up possibilities to treat several chronic diseases, such as diabetes, neurological and cardiovascular diseases, affecting millions of patients worldwide. LÄS MER