Sökning: "DFMO"
Visar resultat 1 - 5 av 7 avhandlingar innehållade ordet DFMO.
1. The Polyamine Dependence of Cell Cycle Progression-Application in Breast Cancer Treatment
Sammanfattning : In the normal functioning organism, there is a balance between cell proliferation, cell differentiation, and cell death. An imbalance in these processes results in different diseases. This thesis concerns the imbalance where there is too little cell death and cell differentiation with increased cell proliferation. LÄS MER
2. Development of analytical methods for determination of drugs, used against tropical diseases, in biological fluids
Sammanfattning : The overall aim of this thesis was to develop analytical methods for determination of drugs, used against tropical diseases, in biological fluids. For the treatment of malaria, piperaquine (PQ) is used in combination with another antimalarial. LÄS MER
3. Drug Analysis : Bioanalytical Method Development and Validation
Sammanfattning : This thesis describes bioanalytical methods for drug determination in biological matrixes, with drugs in focus used against diseases largely affecting low-income countries. Solid-phase extraction is used for sample cleanup, and processed samples are analyzed by liquid chromatography. LÄS MER
4. Development and Validation of Bioanalytical Methods : Application to Melatonin and Selected Anti-Infective Drugs
Sammanfattning : This thesis describes bioanalytical methods for measuring melatonin and some anti-infective drugs in biological fluids. Solid-phase extraction (SPE) or protein precipitation was used for enrichment and purification of the analytes and Liquid Chromatography (LC) was used to analyze the samples. LÄS MER
5. Polyamines are involved in the regulation of S phase and DNA synthesis
Sammanfattning : Our research group has previously shown that treatment with the polyamine biosynthesis inhibitors a-difluoromethylornithine (DFMO) or amidinoindan-1-one 2´-amidinohydrazone (CGP 48664) inhibited S phase progression before any other cell cycle phase was affected. This study was undertaken to further investigate the role of polyamines in the regulation of S phase progression and DNA synthesis. LÄS MER