Sökning: "D1-agonist"

Hittade 5 avhandlingar innehållade ordet D1-agonist.

  1. 1. Morphological and Physiological Adaptations in Cichlid Crystalline Lenses

    Författare :Marcus Schartau; Biologiska institutionen; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; SKF-38393; D1-agonist; optical properties 6-hydroxydopamine; optical measurements; organ culture; dopamine; teleost; lens circulation; Lens; SCH-23390; melatonin; multifocal optical system;

    Sammanfattning : Vertebrate eyes share a common ancestry as well as the basic design with a pupil, a retina and a lens. The lens is essential for perceiving the details in the world around us and ensures that a sharp image of the surroundings is focused onto the photoreceptors in the retina. LÄS MER

  2. 2. The functional role of the lateral olivocochlear system and mechanisms underlying sound condtioning

    Författare :Xianzhi Niu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; Cochlea; dopamine; tyrosine hydroxylase; sound conditioning; apoptosis; acoustic trauma; lateral olivocochlear nucleus; D1 receptor; efferents;

    Sammanfattning : Sound conditioning is a process induced by a low-level, non-damaging acoustic stimulus that provides protection against subsequent detrimental forms of acoustic trauma. Many hypotheses have been advanced to explain the effect of sound conditioning, but the mechanisms underlying this phenomenon are still not yet known. LÄS MER

  3. 3. Behavioural and biochemical pharmacology of adenosine/dopamine receptor/receptor interaction

    Författare :Roberto Rimondini-Giorgini; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; Adenosine; A; receptors; A2A receptors; dopamine; D1 receptors; D2 receptors; mGluR receptors; striatum; immediately early genes; c-fos; junB; NGFI-A; microdialysis; receptor binding; in situ hybridisation;

    Sammanfattning : The neurotransmitter dopamine seems to be involved in neuropsychiatric diseases such as schizophrenia and Parkinson's disease. Direct blockade of dopamine receptors of the D2 subtype has been the hallmark of pharmacotherapy for schizophrenia since early 1950s. LÄS MER

  4. 4. Emerging pharmacotherapies for Parkinson's Disease: Experimental studies in the rat

    Författare :Hanna Iderberg; Basala gangliernas patofysiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Parkinson s Disease; L-DOPA; L-DOPA-induced dyskinesia; rat model of Parkinson s disease; behavioural pharmacology;

    Sammanfattning : Parkinson´s disease (PD) is a neurodegenerative disorder characterized by the typical motor symptoms, akinesia/bradykinesia, rigidity and resting tremor. These symptoms are caused by a deficiency of dopamine (DA) in the brain, which depends on degeneration of DA neurons in the substantia nigra. LÄS MER

  5. 5. Dissecting the intrastriatal neuronal circuitry that regulates direct and indirect striatal projections

    Författare :Henrike Planert; Karolinska Institutet; Karolinska Institutet; []

    Sammanfattning : The basal ganglia (BG) are a group of subcortical nuclei that are interconnected in multiple parallel cortico-BG-thalamocortical loops. They have been implicated in many functions, among them action control and motor learning. The striatum forms the main input nucleus of the BG. LÄS MER