Sökning: "Cysteine proteases"
Visar resultat 1 - 5 av 27 avhandlingar innehållade orden Cysteine proteases.
1. Studies on secreted cysteine proteases of Streptococcus pyogenes : IdeS and SpeB
Sammanfattning : The pathogen Streptococcus pyogenes is a significant cause of human morbidity and mortality. Most of the work in this thesis is focused on streptococcal virulence factor IdeS, but the thesis also features work on SpeB, another streptococcal virulence factor. LÄS MER
2. Characterization of secreted Giardia intestinalis cysteine proteases
Sammanfattning : Giardia intestinalis, the causative agent of the diarrheal disease giardiasis, is a protozoan parasite that colonizes the upper small intestine of mammals, including humans. It can be divided into eight genotypes or assemblages (A through H) and only assemblage A and B are infective to humans. LÄS MER
3. Cystatin C functions in vitro and in vivo. Studies on target enzyme inhibition by cystatin C variants and cystatin C deficient mice
Sammanfattning : Cystatin C variants with Arg8, Leu9 and/or Val10 replaced by Gly residues were produced by site-directed mutagenesis and E. coli expression. LÄS MER
4. Dendritic cell presentation of type II collagen
Sammanfattning : Type II collagen (CII) is the main protein component of cartilage and immune recognition of CII plays a critical role for the development of collagen induced arthritis (CIA), a widely used animal model for rheumatoid arthritis (RA). Antigen presentation is an important requirement for the immune response, the more efficient presentation of the antigen the better tolerance will be induced and thereby protect against arthritis. LÄS MER
5. Matrix degrading proteases in vascular disease
Sammanfattning : Diverse processes of vascular disease including lesion growth, plaque rupture and abdominal aortic aneurysm formation are influenced by protease expression. Arteries undergo compensatory remodelling when the mechanical forces that are imposed on them are altered. LÄS MER