Sökning: "Cyclization"

Visar resultat 1 - 5 av 41 avhandlingar innehållade ordet Cyclization.

  1. 1. Palladium(II)-Catalyzed Oxidative Cyclization Strategies : Selective Formation of New C-C and C-N Bonds

    Författare :Andreas K. Å. Persson; Jan-Erling Bäckvall; Matthew Sigman; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Carbocyclization; Palladium Catalysis; Oxidation; Cyclization; Enallenes; Aza-Enallenes; Dienallenes; Allenylation; Oxazolidinones; Biomimetic; Arylation; Borylation; Transmetallation; organisk kemi; Organic Chemistry;

    Sammanfattning : The main focus of this thesis has been directed towards preparation and oxidative carbocyclization of en-, dien- and aza-enallenes.In the first part of this thesis, a stereoselective oxidative carbocyclization of dienallenes was realized. LÄS MER

  3. 2. Construction of Five-Membered Heterocyclic Compounds via Radical Cyclization

    Författare :Stefan Berlin; Lars Engman; Mario D. Bachi; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Organic chemistry; radical; cyclization; carbonylation; melatonin; pyrrolidine; pyrrolidin-3-one; tetrahydrofuran-3-one; Organisk kemi; Organic chemistry; Organisk kemi; organisk kemi; Organic Chemistry;

    Sammanfattning : This thesis describes how radical cyclization chemistry can be applied for the construction of heterocyclic compounds.In the first part, a series of electron deficient α-phenylselenenylalkenes were prepared via a PhSeCl-addition/HCl-elimination sequence. LÄS MER

  4. 3. Radical Cyclization Approaches to Pyrrolidines

    Författare :Magnus Beşev; Troels Skrydstrup; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Organic chemistry; Radical cyclization; diastereselectivity; pyrrolidine; pyrroline; thiazoline; aziridine; Organisk kemi; Organic chemistry; Organisk kemi; organisk kemi; Organic Chemistry;

    Sammanfattning : Five-membered rings are readily prepared by 5-exo-trig radical cyclization. This thesis is concerned with novel methodology for pyrrolidine synthesis. We have synthesised selenium containing radical precursors from aziridines and α-phenylseleno ketones, and cyclized them to 2,4- and 3,4-disubstituted pyrrolidines. LÄS MER

  5. 4. Synthesis of Aldehyde-Functionalized Building Blocks and Their Use for the Cyclization of Peptides : Applications to Angiotensin II

    Författare :Petra Johannesson; Rob M. J. Liskamp; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical chemistry; Synthesis; Aldehyde; Cyclization; Peptide; Angiotensin II; Ang II; Bioactive Conformation; Solid Phase Peptide Synthesis; Dimethyl Acetal; Farmaceutisk kemi; Syntes; Aldehyd; Cyklisering; Peptid; Bioaktiv konformation; Fast-fas peptidsyntes; Dimetylacetal; Pharmaceutical chemistry; Farmaceutisk kemi; Organic Pharmaceutical Chemistry; organisk farmaceutisk kemi;

    Sammanfattning : This study addresses the issue of how to convert peptides into drug-like non- peptides with retained biological activities at peptide receptors. Angiotensin II (Asp-Arg-Val-Tyr-Ile-His-Pro-Phe, Ang II) was used as a model peptide. LÄS MER

  7. 5. Pyrrolidines via Radical Cyclization

    Författare :Magnus Besev; Uppsala universitet; []
    Nyckelord :;

    Sammanfattning : .... LÄS MER