Sökning: "Crohn s disease"

Visar resultat 16 - 20 av 22 avhandlingar innehållade orden Crohn s disease.

1. 16. T Cell Ontogeny and Effector Functions in Galphai2-deficient Colitis

   Författare :Malin Bjursten; Göteborgs universitet; []
   Nyckelord :colitis; T cells; Galphai2- - mice; thymus; pro-inflammatory cytokines; alpha4 integrin;

   Sammanfattning : Inflammatory bowel disease (IBD) comprising Crohn s disease and ulcerative colitis is a disease that affects millions of people worldwide, especially in northern countries such as Sweden, and is characterised by chronic uncontrolled inflammation of the intestinal mucosa. It is the general belief that multiple factors such as genetic and environmental aspects are involved in disease pathogenesis. LÄS MER

3. 17. The functional role of the MUC17-based glycocalyx

   Författare :Sofia Jäverfelt; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Intestine; Glycocalyx; Membrane mucin; Host defenses;

   Sammanfattning : Our gastrointestinal tract harbors trillions of bacteria that are chemically and spatially separated from the intestinal epithelium. Maintaining an intact mucosal barrier is essential as increased bacterial contact is associated with inflammatory bowel diseases such as Crohn´s disease. LÄS MER

4. 18. Identification and characterization of WASP and FKBP-like protein

   Författare :Ing-Marie Viklund; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Ulcerative colitis (UC) is a chronic inflammation of the colon which together with the related Crohn s disease (CD) represent the major forms of Inflammatory Bowel Disease (IBD). IBD is believed to arise in a dysfunctional intestinal barrier which allows the normal gut flora to trigger an unwanted chronic immune response in genetically susceptible individuals. LÄS MER

5. 19. Genetic Variation and Expression of the IRF5 Gene in Autoimmune Diseases

   Författare :Gudlaug Thora Kristjansdottir; Ann-Christine Syvänen; Lars Rönnblom; Gunnel Nordmark; Unnur Þorsteinsdóttir; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medical genetics; Medicinsk genetik; Genetics; genetik;

   Sammanfattning : The interferon regulatory factor 5 (IRF5) gene encodes a transcription factor that plays an important role in the innate as well as in the cell-mediated immune response. The IRF5 gene has received considerable attention since it was shown to be associated with two autoimmune diseases; systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). LÄS MER

7. 20. Regulation of mucosal inflammation by fibroblasts

   Författare :Tanya (De L.) Karlson; Göteborgs universitet; []
   Nyckelord :inflammatory bowel diseases; fibroblasts; CD40; C-EBPbeta; apoptosis; TGF-beta;

   Sammanfattning : ABSTRACT Acute inflammation in the bowel, a response of the immune system to infections or trauma, is probably a frequent but localized event, but when the barrier is repaired and the infection cleared, it is quickly followed by wound healing and resolution. However, in some individuals these mechanisms are not effective and the inflammatory bowel diseases, Crohn?s disease and ulcerative colitis result. LÄS MER