Sökning: "CpG DNA"

Visar resultat 21 - 25 av 85 avhandlingar innehållade orden CpG DNA.

1. 21. Influence of genetic polymorphisms on DNA repair, p53 mutations and cancer risk

   Författare :Charlotta Ryk; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :polymorphisms; metabolism; DNA repair; p53; lung cancer; bladder cancer;

   Sammanfattning : Individuals have different susceptibility towards environmental exposures that may cause or contribute to disease. This inter-individual variation is partly due to genetic polymorphisms in genes involved in DNA repair and metabolism, which have potential to modulate the function of the encoded proteins. LÄS MER

3. 22. Cancer Immunotherapy : A Preclinical Study of Urinary Bladder Cancer

   Författare :Christina Ninalga; Thomas Tötterman; Magnus Essand; Timothy Ratliff; Uppsala universitet; []
   Nyckelord :Medicine; immunotherapy; bladder carcinoma; cancer; CpG ODNs; Adenoviral vector; CD40L; TRANCE; Lymphotactin; IL2; IL15; Medicin;

   Sammanfattning : Bacillus Calmette Guérin (BCG), or attenuated Mycobacterium bovis, is the gold standard of immunotherapy in the clinic to treat superficial bladder cancer. However, setbacks remain due to a high recurrence rate, side effects, and BCG-refractory disease. LÄS MER

4. 23. Epigenetic and Gene Expression Signatures in Systemic Inflammatory Autoimmune Diseases

   Författare :Juliana Imgenberg-Kreuz; Gunnel Nordmark; Ann-Christine Syvänen; Johanna K Sandling; Amr Sawalha; Uppsala universitet; []
   Nyckelord :Autoimmunity; DNA methylation; Primary Sjögren’s syndrome; Systemic lupus erythematosus; Gene expression; Type I interferon system; Epigenetics; Medicinsk vetenskap; Medical Science;

   Sammanfattning : Autoimmune diseases are clinical manifestations of a loss-of-tolerance of the immune system against the body’s own substances and healthy tissues. Primary Sjögren’s syndrome (pSS) and systemic lupus erythematosus (SLE) are two chronic inflammatory autoimmune diseases characterized by autoantibody production and an activated type I interferon system. LÄS MER

5. 24. Epigenetic dysregulation in relation to psychiatric traits in adolescence and adulthood

   Författare :Adrian Desai Boström; Helgi B. Schiöth; Daniel Nätt; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; methylome-wide; DNA methylation; hypersexual disorder; microRNA; oxytocin signaling; psychiatry; hsa-miR-4456; microRNA-4456; MIR4456; epigenetic dysregulation; microRNA expression; gene target prediction; epigenetics; suicide; suicide attempt; HPA axis; CRH gene; Epigenetics; Methylation; Adolescent depression; MIR4646; methylome-wide association study; Omega-3; mQTL analysis; GAD1; HDAC3; DAWBA;

   Sammanfattning : Epigenetics has evolved into a key research focus in the field of psychiatry. DNA methylation is the most researched epigenetic mechanism. In paper I-III, 130 and 93 adolescents were randomly recruited at two separate intervals. LÄS MER

7. 25. Nucleotide Substitution Patterns in Vertebrate Genomes

   Författare :Carina Farah Mugal; Hans Ellegren; Ziheng Yang; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; nucleotide substitutions; mutation rate variation; strand asymmetries; CpG effect; GC-biased gene conversion; codon evolution; Biologi med inriktning mot molekylär evolution; Biology with specialization in Molecular Evolution;

   Sammanfattning : The rates and patterns at which nucleotide substitutions occur vary significantly across the genome sequence of vertebrates. A prominent example is the difference in the rate of evolution of functional sequences versus nonfunctional (neutrally evolving) sequences, which is explained by the influence of natural selection on functional sequences. LÄS MER