Sökning: "CpG DNA"

Visar resultat 16 - 20 av 85 avhandlingar innehållade orden CpG DNA.

  1. 16. Aberrant DNA methylation in acute myeloid leukemia

    Författare :Ying Qu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : DNA methylation is an important epigenetic mechanism that influences development and cancer by regulating gene transcription. Aberrant DNA methylation is a feature of cancer including acute myeloid leukemia (AML). LÄS MER

  3. 17. IDO gene expression induction by DNA methylation inhibitors

    Författare :Hua Liu; Neurokirurgi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : The aim was to study the effect of DNA methylation of CpG motifs in cancer cells and immune cells by use of the DNA methyltransferas (DNMT) inhibitor zebularine. In cancer cells it is known that genes can be silenced by chromosomal deletion(s). It is also known that genes can be silenced by DNA methylation or expression of micro-RNA. LÄS MER

  4. 18. Locus specific DNA methylation in human immunological responses

    Författare :Emma Ahlén Bergman; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : All cells in the human body contains the same genome. Yet, there are hundreds of different cell types, with widely different phenotype, and function. The differential gene expression leading to this diversity is tightly regulated by epigenetics, i.e. LÄS MER

  5. 19. Induction of t-cell responses against PSA by plasmid DNA immunization

    Författare :Maxim Pavlenko; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Prostate-specific antigen; DNA vaccine; cytotoxic T lymphocytes;

    Sammanfattning : This thesis is focused on using plasmid DNA encoding human prostate-specific antigen (PSA) for immunotherapy of prostate cancer. PSA is a secreted serine protease, which is produced almost exclusively by prostate epithelial cells. LÄS MER

  7. 20. Prognostic markers and DNA methylation profiling in lymphoid malignancies

    Författare :Sujata Bhoi; Richard Rosenquist Brandell; H Denis Alexander; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Lymphoid malignancies; CLL; MCL; prognostic markers; micro-RNA; methylation; stereotyped subsets;

    Sammanfattning : In recent years, great progress has been achieved towards identifying novel biomarkers in lymphoid malignancies, including chronic lymphocytic leukemia (CLL) and mantle cell lymphoma (MCL), at the genomic, transcriptomic and epigenomic level for accurate risk-stratification and prediction of treatment response. In paper I, we validated the prognostic relevance of a recently proposed RNA-based marker in CLL, UGT2B17, and analyzed its expression levels in 253 early-stage patients. LÄS MER