Sökning: "CpG DNA"

Visar resultat 11 - 15 av 85 avhandlingar innehållade orden CpG DNA.

  1. 11. Genome-wide epigenetic profiling of B cell leukemia and lymphoma

    Författare :Mohammad Hamdy Abdelrazak Morsy; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CLL; PRC2; EZH2; Epigenetics; CpG islands; DNA methylation; ChIP-seq; RNA-seq;

    Sammanfattning : Epigenetic modifications, at the level of DNA methylation and post-translational modifications of histone tails cooperatively function in the organization of the genome, and thereby establish the gene expression profiles, phenotypes, and cellular fates. In this work, we investigated the aberrant epigenome in chronic lymphocytic leukemia (CLL) which is one of the most frequent lymphoid malignancies in the west including the Nordic countries. LÄS MER

  3. 12. Biological signature of HER2-positive breast cancer

    Författare :Breezy Malakkaran Lindqvist; Sten Wingren; Torbjörn Nilsson; Ingrid Hedenfalk; Örebro universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; HER2 breast cancer; SLC25A43; CpG island; DNA methylation; Homeobox genes; FOXO3a; FOXG1; Biomedicin; Biomedicine;

    Sammanfattning : Human epidermal growth factor receptor 2 (HER2) overexpressing breast cancers (HER2+ breast cancer) are associated with an aggressive disease course. This thesis is focused on improving the understanding of the biological signature of HER2+ breast cancer. LÄS MER

  4. 13. Enhancement of HIV-1 DNA immunogens

    Författare :Anne Kjerrström Zuber; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :HIV-1; DNA vaccination; regulatory genes; adjuvants; experimental HIV-1 model;

    Sammanfattning : Human immunodeficiency virus type 1 eludes control by the immune response through a high degree of variability and immune escape mechanisms. Induction of a broad specific immune response is important to clear virus-infected cells. LÄS MER

  5. 14. Computational discovery of DNA methylation patterns as biomarkers of ageing, cancer, and mental disorders : Algorithms and Tools

    Författare :Behrooz Torabi Moghadam; Jan Komorowski; Manfred Grabherr; Jaak Vilo; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; DNA methylation; machine learning; biomarker; cancer; ageing; classification;

    Sammanfattning : Epigenetics refers to the mitotically heritable modifications in gene expression without a change in the genetic code. A combination of molecular, chemical and environmental factors constituting the epigenome is involved, together with the genome, in setting up the unique functionality of each cell type. LÄS MER

  7. 15. Suppressive DNA vaccination in experimental autoimmune encephalomyelitis

    Författare :Anna Lobell; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :DNA vaccination; autoimmunity; experimental autoimmune encephalomyelitis; multiple sclerosis; T cell receptor; CpG motif; myelin basic protein; myelin oligodendrocyte glycoprotein;

    Sammanfattning : This thesis describes the development of a novel method to suppress an organ-specific autoimmune disease, experimental autoimmune encephalomyelitis (EAE), by vaccination with DNA encoding autoantigenic peptides. DNA vaccination can produce long-term immunity and generate antigen-specific CD8+ and CD4+ T cells. LÄS MER