Sökning: "Coxsackie virus B"

Visar resultat 1 - 5 av 8 avhandlingar innehållade orden Coxsackie virus B.

  1. 1. Coxsackie B virus pathogenesis in mice

    Författare :Maria Hindersson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Coxsackie B virus (CVB) belongs to the enterovirus (EV) genera of the Picornaviridae family. These infections range from asymptomatic, mild infections to serious diseases such as myocarditis, pancreatitis, paralysis, aseptic meningitis and encephalitis. LÄS MER

  3. 2. Enterovirus Implications in Type 1 Diabetes

    Författare :Monika Hodik; Hober didier; Uppsala universitet; []
    Nyckelord :Enterovirus; Coxsackie B virus; Type 1 diabetes; Pancreatitis;

    Sammanfattning : Human enteroviruses (HEVs), particularly Coxsackie B viruses (CVBs), might trigger the onset of type 1 diabetes (T1D), either by direct infection of the insulin-producing beta-cells or by an indirect inflammatory response. The overall aim of this thesis was to study the tropism of HEVs in isolated human pancreatic cell clusters in vitro including virus effects on islet function, gene-expression and ultrastructure. LÄS MER

  4. 3. Autoimmune markers in autoimmune diabetes

    Författare :Manu Gupta; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :HLA; MICA; type 1 diabetes; LADA; Coxsackie virus B; autoantibodies; newborn screening;

    Sammanfattning : Type 1 diabetes mellitus (T1DM) is an autoimmune disease, characterized by autoimmune mediated loss of insulin secreting Beta-cells. The disease is associated with certain HLA class 11 haplotypes. HLA DR3-DQ2 and DR4-DQ8 are positively while DQ6 (DQA1*0102-DQB1*0602) is negatively associated with the disease in Caucasians. LÄS MER

  5. 4. Degradomics : a study of the cellular proteolytic landscape in enterovirus infections

    Författare :Sebastian Kapell; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The common human pathogen, enteroviruses (EVs) are a genus of single stranded RNA viruses that include Coxsackie B virus (CVBs). The viral RNA encodes a polyprotein containing two viral proteases 2Apro and 3Cpro, that process the polyprotein into structural and non-structural proteins during virus replication. LÄS MER

  7. 5. The glycobiology of human adenovirus infections : implications for tropism and treatment

    Författare :Naresh Chandra; Niklas Arnberg; Lars Frängsmyr; Gunnel Haldén; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; denovirus; cellular receptor; glycosaminoglycan; sialic acid; decoy receptors; tropism; epidemic keratoconjunctivitis; antiviral drugs; GAG-mimetic; obesity; medicinsk virologi; Medical Virology;

    Sammanfattning : Human adenoviruses (HAdVs) are common human pathogens, causing gastrointestinal, ocular, and respiratory infections on a regular basis. Epidemic keratoconjunctivitis (EKC) is a severe ocular infection for which no approved antivirals are available. LÄS MER