Sökning: "Costimulation"
Visar resultat 11 - 15 av 23 avhandlingar innehållade ordet Costimulation.
11. Experimental islet transplantation
Sammanfattning : Pancreatic islet transplantation is a promising treatment modality for patients with insulin- dependent diabetes. Besides whole pancreas transplantation, it is the only treatment that can make patients normoglycemic without risking episodes of hypoglycemia. LÄS MER
12. Engraftment and tolerance induction in cellular therapy : focus on mesenchymal stromal cells
Sammanfattning : Different cell types have been employed in the search for a cellular therapy that is applicable for the treatment of heart failure. Remuscularization strategies using stem-cell-derived cardiomyocytes have been prone to arrhythmias. LÄS MER
13. Cell transplantation with human mesenchymal or embryonic stem cells to the heart : experimental, molecular, immunological and echocardiographic studies
Sammanfattning : Background: Human mesenchymal stem cells (hMSC), human embryonic stem cells (HESC) and human fetal cardiomyocyte progenitor cells (HFCP) all represent possible candidate cells for regeneration of damaged myocardium. Although they represent cell types with many positive attributes, their capacity to engraft, to differentiate into mature cardiomyocytes, to improve myocardial function and their immunological properties are the focus of these studies. LÄS MER
14. Tumor necrosis factor superfamily members CD137 and OX40 ligand in vascular inflammation
Sammanfattning : Atherosclerosis, an inflammatory disease, is the major cause of cardiovascular disease - the main cause of death worldwide. T cells are central orchestrators of inflammation in atherosclerosis and critically depend on costimulation for adequate function. LÄS MER
15. Embryonic and adult cardiac stem cells : molecular, electrophysical and immunological characteristics for cardiac repair
Sammanfattning : Background: The concept of myocardial regeneration by means of stimulating the endogenous regenerative potential in situ is an attractive approach. This offers distinct advantages to stem cell implantation where the problems with engraftment and immune rejection are avoided. LÄS MER