Sökning: "Cortical contusion injury"

Visar resultat 1 - 5 av 12 avhandlingar innehållade orden Cortical contusion injury.

  1. 1. Secondary injury mechanisms in brain trauma : a study of cerebral cortical contusion in the rat

    Författare :Pelle Nilsson; Uppsala universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : .... LÄS MER

  3. 2. Mechanisms of traumatic brain injury in the rat : Morphological consequences and neurotrophic responses

    Författare :Anders Lewén; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurosciences; Cortical contusion injury; TBI; neurons; axons; dendrites; APP; MAP2; BMPR-II; ActR-I; trkB; c-fos; BDNF; PACAP; TUNEL; TGFs; serine threonine; bone morphogenetic protein; neuropeptides; reactive oxygen species; ROS; apoptosis; Neurovetenskap; Neurology; Neurologi; Neurosurgery; neurokirurgi;

    Sammanfattning : Traumatic brain injury is a major cause of death and disability in the Western world. especially in young people. Understanding the pathophysiology of traumatic brain injury is the basis for further development of better therapeutic strategies for such patients. LÄS MER

  4. 3. The role of reactive oxygen species in traumatic brain injury : Experimental studies in the rat

    Författare :Niklas Marklund; Uppsala universitet; []
    Nyckelord :Medical sciences; Apoptosis; CBF; controlled cortical contusion injury; 3; 4-dihydroxybenzoate; fluid percussion injury; glucose; 4-hydroxybenzoate; microdialysis; Morris Water Maze; neuroprotection; nitrones; PBN; rat; reactive oxygen species ROS ; salicylate; S-PBN; TBI; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; Neurosurgery; neurokirurgi;

    Sammanfattning : Traumatic brain injury (TBI) is a major cause of mortality and disability. As common sequelae in survivors of TBI are disabling functional, emotional and cognitive disturbances, improved treatment of TBI patients is urgently needed. At present, no neuroprotective pharmacological treatment exists. LÄS MER

  5. 4. The Role of Cyclooxygenase-2 in Models of Epilepsy and Traumatic Brain Injury : Effects of Selective Cyclooxygenase-2 Inhibitors

    Författare :Tina Kunz; Tadeusz Wieloch; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biosciences; Controlled cortical contusion injury; fluid percussion injury; limbic seizures; nuclear factor-kappa B; prostaglandin metabolism; TUNEL staining; Farmaceutisk biovetenskap; Biopharmacy; Biofarmaci; farmaceutisk farmakologi; Pharmaceutical Pharmacology;

    Sammanfattning : Cyclooxygenase-2 (COX-2) catalyses prostaglandin synthesis from arachidonic acid during inflammation. COX-2 is expressed in the normal brain and is induced in neurological disorders. There is evidence that COX-2 is involved in secondary events leading to cell death in the brain. LÄS MER

  7. 5. Brain injury biomechanics in closed-head impact : studies on injury epidemiology, tolerance criteria, biomechanics and traffic injury prevention

    Författare :David Viano; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Closed-head impact; brain injury; biomechanics; injury mechanisms; tolerance criteria; epidemiology; and primary prevention.;

    Sammanfattning : Permanent disability from traumatic brain injury is a devastating consequence of traffic crashes. Injury prevention is a fruitful approach to reduce the incidence and severity of disabling brain injury. LÄS MER