Sökning: "Constantin Urban"

Hittade 5 avhandlingar innehållade orden Constantin Urban.

  1. 1. The Impact of Tryptase and Epigenetic Mechanisms on Mast Cells

    Författare :Sultan Alanazi; Gunnar Pejler; Constantin Urban; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; mast cells; mastocytosis; tryptase; histone; DNA; methylation; neutrophil extracellular traps; Immunologi; Immunology;

    Sammanfattning : Mast cells have a large influence on multiple immune-mediated responses, including allergic conditions, and they have been implicated in various diseases such as arthritis and cancer. Mastocytosis is characterized by abnormal mast cell proliferation induced by mutations in KIT, the stem cell factor (SCF) receptor. LÄS MER

  3. 2. Modulation of neutrophil extracellular trap formation in health and disease

    Författare :Ava Hosseinzadeh; Constantin F. Urban; Carol Munro; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neutrophils; Candida albicans; Adenosine; Tempol; Nicotine; molekylärbiologi; Molecular Biology;

    Sammanfattning : The critical prompt innate immune response is highly built upon the influx of neutrophils from the blood stream to the site of infection. In the battlefield, neutrophils sense pathogen-associated molecular patterns (PAMPs) through their pattern-recognition receptors (PRRs) to launch a number of responses with the goal to defeat the invading pathogen. LÄS MER

  4. 3. Candida albicans adaption to host microenvironments drives immune evasion

    Författare :José Pedro Lopes; Constantin F. Urban; Alistair Brown; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; fungi; candida albicans; neutrophils; mast cells; immune evasion; mycoses; infectious diseases; immunologi; Immunology; Infectious Diseases; infektionssjukdomar; Molecular Immunology; molekylär immunologi;

    Sammanfattning : Immunosuppressed patients are frequently afflicted with severe mycoses caused by opportunistic fungal pathogens. Besides being a commensal colonizing predominantly skin and mucosal surfaces, Candida albicans is the most common human fungal pathogen. LÄS MER

  5. 4. Neutrophils versus Pathogenic Fungi : through the magnifying glass of nutritional immunity

    Författare :Maria Joanna Niemiec; Constantin F. Urban; Bernhard Hube; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neutrophils; Candida albicans; nutritional immunity; metallome; Zn; Fe;

    Sammanfattning : Neutrophils are among the first white blood cells recruited to the site of infection once microbial pathogens enter the host organism. At site, they perform a well-orchestrated chain of processes that aims to kill the microbial invader. Most prominent, neutrophils engulf microbes to inactivate them intracellularly, a process called phagocytosis. LÄS MER

  7. 5. Pharmaceutical And Immunollogical Challenge Of Fungal Pathogens

    Författare :Marios Stylianou; Constantin F. Urban; Christophe d' Enfert; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; mast cells; Candida albicans; yeast to hyphal form; antifungal drugs; repurposed drugs; HTS;

    Sammanfattning : Incidences of fungal infections are on the rise in immunosuppressed people. Predominant causative agents for these mycoses are species of the genus Candida, including Candida albicans, Candida glabrata and Candida dublieniensis. Despite a wide range of emerging pathogens, C. albicans remains the leading cause. LÄS MER