Sökning: "Conformation analysis"
Visar resultat 1 - 5 av 125 avhandlingar innehållade orden Conformation analysis.
1. Synthesis and analysis of carbohydrates related to bacterial polysaccharides
Sammanfattning : The outer surface of bacteria is composed of around 75% carbohydrates, which are vital for the bacteria to survive and communicate with the host biological system. The thesis discusses different properties of carbohydrates that are essential for understanding the bacterial behavior in biological systems. LÄS MER
2. Assembling and Unraveling Carbohydrates Structures : Conformational analysis of synthesized branched oligosaccharides
Sammanfattning : Advances in the elaboration of vaccines and enzyme inhibitors rely on acquiring more knowledge about protein-carbohydrate binding events. Furthermore, the relationships between biological function and the three-dimensional properties of large glycans can be studied by focusing on the structural components they contained, namely, by scaling down the system under analysis. LÄS MER
3. Structural Studies of O-antigen polysaccharides, Synthesis of 13C-labelled Oligosaccharides and Conformational Analysis thereof, using NMR Spectroscopy
Sammanfattning : In order to understand biological processes, to treat and diagnose diseases, find appropriate vaccines and to prevent the outbreak of epidemics, it is essential to obtain more knowledge about carbohydrate structures. This thesis deals with structure and conformation of carbohydrates, analysed by NMR spectroscopy and MD simulations. LÄS MER
4. The solution conformations of macrocycles. Applications in the exploration of weak interactions and in drug development
Sammanfattning : Understanding the solution conformation and dynamics of molecules with biological relevance, as well as the impact of their conformation stabilizing weak interactions, is for example important for drug design. Macrocycles have attractive pharmaceutical properties, and are of special interest as drug leads for targets with large, flat and featureless binding sites like protein-protein interfaces. LÄS MER
5. Modulation of Molecular Properties : Host–Guest Interactions for Structural Analysis and Chemical Reactions
Sammanfattning : This thesis concerns the construction, use and modulation of various host–guest systems, from small bispidines for binding of inorganic ions to bisporphyrin clips for supramolecular systems.Small flexible molecules undergo fast conformational movements when in solution. LÄS MER