Sökning: "Conditional beta"

Visar resultat 1 - 5 av 12 avhandlingar innehållade orden Conditional beta.

  1. 1. Smad signaling in hematopoietic stem cell biology

    Författare :Göran Karlsson; Avdelningen för molekylärmedicin och genterapi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Smad7; Smad4; microarray; retroviral-mediated gene expression; conditional knockout; transforming growth factor beta; smad signaling; hematopoiesis; hematopoietic stem cells; Alk5; Medicine human and vertebrates ; Medicin människa och djur ;

    Sammanfattning : Hematopoietic stem cells (HSCs) are primitive tissue-specific somatic stem cells, responsible for the maintenance and replenishment of the bone marrow (BM) and subsequently the entire blood system. The never-ending ability to differentiate into all the mature hematopoietic lineages makes these HSCs attractive candidates for use in future regenerative medicine. LÄS MER

  3. 2. Regulation of hematopoiesis by the Smad signaling pathway

    Författare :Ulrika Blank Savukinas; Avdelningen för molekylärmedicin och genterapi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicine human and vertebrates ; retroviral mediated gene expression; conditional knockout; hematopoietic stem cell; hematopoiesis; Transforming growth factor-beta; Smad signaling; Medicin människa och djur ;

    Sammanfattning : Hematopoietic stem cells (HSCs) reside in the bone marrow (BM) of adult individuals and are ultimately responsible for the continuous production of blood cells throughout life. The regulation of HSCs in vivo is tightly regulated by both intrinsic and extrinsic factors. LÄS MER

  4. 3. THE ROLE OF BMP SIGNALING AND ENDOGLIN IN REGULATION OF HEMATOPOIESIS

    Författare :Sofie Singbrant; Avdelningen för molekylärmedicin och genterapi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TGF-beta superfamily signaling; Conditional knockout mouse; Hematopoietic Stem Cell; Hematopoiesis; Endoglin; BMP;

    Sammanfattning : Hematopoiesis, the formation of blood cells, ultimately depends on a rare population of hematopoietic stem cells (HSCs), which can both self-renew to maintain the HSC pool, and differentiate into all mature blood lineages. HSC fate decisions are governed by a complex combination of numerous signals, although the molecular mechanisms are not fully understood. LÄS MER

  5. 4. Interplay between autophagy and amyloid beta metabolism in Alzheimer’s disease

    Författare :Richeng Jiang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Alzheimer’s disease (AD), the most common neurodegenerative disease, is characterized by two pathological hallmarks: extracellular amyloid-beta peptide (Aβ) plaque depositions and neurofibrillary tangles (NFTs) composed of intracellular hyperphosphorylated tau aggregations. A cellular degradation system, autophagy is additionally dysfunctional in AD and plays a key role in Aβ and tau metabolisms. LÄS MER

  7. 5. Regulation of microglia and monocyte function by the cytokine TGF-beta

    Författare :Harald Lund; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : It has been almost a century since Pío del Río-Hortega described the microglial cell, proposing it to be primarily occupied with phagocytosis of waste products. While this makes up one of its functions, we know today that microglia participate in numerous tasks and can interact with and regulate all other cell types of the brain. LÄS MER