Sökning: "Complement regulation"

Visar resultat 21 - 25 av 101 avhandlingar innehållade orden Complement regulation.

1. 21. B cells in Autoimmunity : Studies of Complement Receptor 1 & 2 and FcγRIIb in Autoimmune Arthritis

   Författare :Kajsa Prokopec; Sandra Kleinau; Anna Erdei; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; B cells; complement receptors; fc gamma receptor IIb; autoimmune arthritis; rheumatoid arthritis; Immunology; Immunologi;

   Sammanfattning : B cells are normally regulated to prevent activation against self-proteins through tolerance mechanisms.  However, occasionally there is a break in tolerance and B cells can become self-reactive, which might lead to the development of autoimmune disease. LÄS MER

3. 22. Initiation of alternative pathway of complement, and development of novel liposomal coatings

   Författare :Anna Adler; Yuji Teramura; Penti Tengvall; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; immunology; complement system; C3; liposomes; polymer-lipids; Immunologi; Immunology;

   Sammanfattning : The complement system is a central part of the innate immune system, and is an essential part in recognizing and clearing non/altered-self surfaces in the body. This thesis comprises of projects in which the initiation of the alternative pathway (AP) of complement in the fluid phase as well on various artificial and lipid surfaces has been studied. LÄS MER

4. 23. Genetic, molecular and functional analyses of factor I - an inhibitor of the complement system

   Författare :Sara Nilsson; Malmö Proteinkemi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; atypical hemolytic uremic syndrome; deficiency; Complement inhibition; factor I; renal disease;

   Sammanfattning : Factor I (FI) is a serine protease that inhibits the complement system by cleaving activated C3 and C4 complement proteins, in the presence of cofactors. Mutations in the gene coding for FI have been identified in complete FI deficient- and atypical hemolytic uremic syndrome (aHUS) patients. LÄS MER

5. 24. Recessive parkinsonism, mitochondria and translational regulation

   Författare :Jeff Blackinton; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Three genes are known to cause recessive forms of Parkinson disease (PD) in humans: parkin, PINK1 and DJ-1. Of these, the rarest is DJ-1; less than fifty known cases worldwide are due to mutations in DJ-1. LÄS MER

7. 25. Modulation of B cell access to antigen by passively administered antibodies : an explanation for antibody feedback regulation?

   Författare :Hui Xu; Birgitta Heyman; Helena Harris; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; IgG; IgG3; IgE; suppression; enhancement; epitope masking; antigen transport; antigen presentation; follicular B cells; marginal zone B cells; Immunologi; Immunology;

   Sammanfattning : Antibody responses can be up- or down-regulated by passive administration of specific antibody together with antigen. Depending on the structure of the antigen and the antibody isotype, responses can be completely suppressed or enhanced up to a 1000-fold of what is seen in animals immunized with antigen alone. LÄS MER