Sökning: "Complement System"

Visar resultat 6 - 10 av 532 avhandlingar innehållade orden Complement System.

  1. 6. The Role of IgM and Complement in Antibody Responses

    Författare :Christian Rutemark; Birgitta Heyman; Claus Nielsen; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Complement; antibody response; mutated IgM; natural IgM; complement receptors; SIGN-R1; SAP; CRP; B cells; Medical Science; Medicinsk vetenskap;

    Sammanfattning : An intact complement system including the complement receptors 1 and 2 (CR1/2) is crucial for the generation of a normal antibody response in animals and humans. Moreover, activation of the classical pathway is thought to be important since deficiency in complement components C1q, C2, C4 or C3 lead to impaired antibody responses. LÄS MER

  3. 7. The role of the complement system in arthritis and stroke

    Författare :Max Albert Hietala; Göteborgs universitet; []
    Nyckelord :complement; C3; factor B; transgenic knockout; arthritis; focal cerebral ischemia;

    Sammanfattning : Complement is part of the innate immune system and functions primarily as a first line of defense against invading microorganisms. It is a complex cascade, which can be activated via three pathways: the classical, alternative and mannan-binding lectin pathway. LÄS MER

  4. 8. Accuracy, efficiency and robustness for rigid particle simulations in Stokes flow

    Författare :Anna Broms; Anna-Karin Tornberg; Mattias Sandberg; Eric Keaveny; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Stokes flow; rigid particles; accuracy; fundamental solutions; method of images; multiblob; contact avoiding; complementarity problem; barrier method; elliptic PDE; grid optimisation; pair-correction; boundary integral equations; Stokesflöde; noggrannhet; stela partiklar; fundamentallösningar; randintegralekvation; reflektionspunkter; multiblob; kontaktundvikande algoritmer; komplementaritetsproblem; barriärmetod; elliptisk PDE; gridoptimering; parkorrektion; Numerical Analysis; Numerisk analys;

    Sammanfattning : The thesis concerns simulation techniques for systems of nano- to micro-scaled rigid particles immersed in a viscous fluid, ubiquitous in nature and industry. With negligible fluid inertia, the set of PDEs known as the Stokes equations can be used to model the hydrodynamics. LÄS MER

  5. 9. Complement Activation Triggered by Biomaterial Surfaces : Mechanisms and Regulation

    Författare :Jonas Andersson; Bo Nilsson; Hans Elwing; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immunology; Biomaterials; Biocompatibility; Blood; Complement; Immunologi; Immunology; Immunologi; klinisk immunologi; Clinical Immunology;

    Sammanfattning : Today there are a vast number of medical devices in temporary or permanent contact with human tissues. Blood-biomaterial contact is known to trigger the complement system and results in generation of fluid phase anaphylatoxins C3a and C5a, and surface-bound C3b and iC3b. LÄS MER

  7. 10. Complement aberrations and autoantibodies to complement proteins in relation to disease mechanisms

    Författare :Lillemor Melander Skattum; immunologi och glykobiologi - MIG Avdelningen för mikrobiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; C3 nephritic factors; GM allotypes; C1q autoantibodies; serum bactericidal activity; Neisseria meningitidis; idiopathic sudden hearing loss; complement; Acute poststreptococcal glomerulonephritis;

    Sammanfattning : The complement system, a part of the innate immune system with several links to the adaptive immune system, plays an important role in the pathogenesis of many diseases. The purpose of this thesis was to document and clarify some of these mechanisms. The thesis is based on four papers (I-IV). LÄS MER