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  1. 1. Rules of engagement - Regulation of complement response in tissue

    Författare :Anas Haider Abu-Humaidan; Infektionsmedicin; []
    Nyckelord :Complement system; Complement activation; Complement regulation; terminal complement complex; Staphylococcus auereus; atopic dermatitis; head and neck cancer; epidermal growth factor receptor; EGFR;

    Sammanfattning : Always in motion and probing for danger, complement proteins are found in every space and notch of the body. Their omnipresence combined with an ability to wreak havoc when activated, mandates a strong leash! The how, when, and where to unleash or constrain the complement response remain partly answered questions, despite the significant progress made in the field in the past 100 years. LÄS MER

  3. 2. Identifying critical components for system reliability in power transmission systems

    Författare :Johan Setréus; Rajeev Thottappillil; Stefan Arnborg; Patrik Hilber; Liisa Haarla; KTH; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; transmission system reliability; component reliability importance index; Great Britain power system; power flow analysis; system adequacy; system security; system vulnerability;

    Sammanfattning : Large interruptions of power supply in the transmission system have considerable impact on modern society. The goal for the transmission system operator (TSO) is to prevent and mitigate such events with optimal decisions in design, planning, operation and maintenance. LÄS MER

  4. 3. The complement system in stherosclerosis and arthritis

    Författare :Linda Persson; Göteborgs universitet; []
    Nyckelord :complement; C3; factor B; ASP; atherosclerosis; hyperlipidemia; arthritis;

    Sammanfattning : The complement system plays an essential role in the humoral immune response. Activated complement has diverse functions, including the initiation of inflammation, recruitment of leukocytes, clearance of immune complexes, neutralization of pathogens, regulation of antibody responses and disruption of cell membranes. LÄS MER

  5. 4. Crosstalk Between Activated Platelets and the Complement System

    Författare :Osama A. Hamad; Bo Nilsson; Kristina Ekdahl-Nilsson; Lennart Truedsson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; platelets; activated platelets; TRAP; chondroitin sulfate; C1q; factor H; C4BP; C3; Compstatin; complement; platelet-leukocyte complexes; platelet microparticles; Clinical immunology; Klinisk immunologi; Klinisk immunologi; Clinical Immunology;

    Sammanfattning : Several studies have shown that complement and thrombotic events co-exist. Platelets have been suspected to act as the bridge between the two cascade systems. LÄS MER

  7. 5. Synaptic elimination and the complement system in Alzhaimer's disease

    Författare :Jonny Daborg; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Synapse; Alzheimer s disease; Genetics; CSF; Complement; RAGE;

    Sammanfattning : The mechanisms behind Alzheimer’s disease (AD) are largely unknown. The disease is to a large extent hereditary, and the best pathophysiological correlate to the severity of the symptoms is loss of synapses. LÄS MER