Sökning: "Compactability"

Visar resultat 1 - 5 av 8 avhandlingar innehållade ordet Compactability.

1. 1. Identification and Variation of some Functionality Related Characteristics of Pharmaceutically Relevant Solid Materials and their Effect on Product Performance

   Författare :Frauke Fichtner; Göran Alderborn; Åke Rasmuson; Peter Kleinebudde; Uppsala universitet; []
   Nyckelord :Pharmaceutics; Particle size distribution; Degree of agglomeration; Amorphous lactose; Matrix agglomerates; Drug release; Compactability; Tablet tensile strength; Particle fracture strength; Surfactant; Compression; Galenisk farmaci;

   Sammanfattning : The aim of this thesis was to identify some functionality related characteristics of pharmaceutically relevant solid materials and to study the effect of their variation on processing behaviour and product performance. For this purpose, particles with different characteristics were prepared under a variety of conditions by crystal agglomeration, wet granulation and spray drying. LÄS MER

3. 2. Investigation of asphalt compaction in vision of improving asphalt pavements

   Författare :Ehsan Ghafoori Roozbahany; Manfred N. Partl; Gabriele Tebaldi; KTH; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Cold asphalt pavement joints; asphalt joint laboratory production; IDT joint evaluation; DTT joint evaluation; 4PB joint evaluation; joints FEM analysis. Discrete Element Modeling DEM ; X-ray Computed Tomography CT ; Compaction Flow Test CFT ; Compactability;

   Sammanfattning : Asphalt joints are potentially weakest parts of every pavement. Despite of their importance, reliable tools for measuring their mechanical properties for design and performance assessments are still scarce. LÄS MER

4. 3. Multivariate Synergies in Pharmaceutical Roll Compaction : The quality influence of raw materials and process parameters by design of experiments

   Författare :Nabil Souihi; Johan Trygg; Jukka Rantanen; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Roll compaction; dry granulation; mannitol; dicalcium phosphate; design of experiments; orthogonal projections to latent structures; critical quality attributes; tablet manufacturing; quality by design; design space; near-infrared chemical imaging; texture analysis; modeling; scale up; instrumented roll; Johanson model;

   Sammanfattning : Roll compaction is a continuous process commonly used in the pharmaceutical industry for dry granulation of moisture and heat sensitive powder blends. It is intended to increase bulk density and improve flowability. LÄS MER

5. 4. Engineering of Pharmaceutical Particles : Modulation of Particle Structural Properties, Solid-State Stability and Tabletting Behaviour by the Drying Process

   Författare :Jonas Berggren; Göran Alderborn; Graham Buckton; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutics; particle engineering; microcrystalline cellulose pellets; intragranular porosity; convective drying; tabletting behaviour; spray-dried composite particles; amorphous lactose; PVP; heat and moisture-induced crystallisation; glass transition temperature; Galenisk farmaci; Pharmaceutics; Galenisk farmaci; galenisk farmaci; Pharmaceutics;

   Sammanfattning : Relationships between stresses during the drying process, particle structural and functional properties, and particle engineering by the drying process were addressed in this thesis. In the first part, the importance of the drying phase and the effect of the drying rate on the intragranular porosity of microcrystalline cellulose pellets were investigated. LÄS MER

7. 5. Experimental approaches to powder filling and lubrication in powder die pressing

   Författare :Erik Hjortsberg; Chalmers tekniska högskola; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; XPS; friction; die filling; interference microscopy; density variations; lubrication; compaction; experimental equipment; tribology; powder metallurgy;

   Sammanfattning : There is a continuous need to improve the mechanical properties of steel parts produced through powder metallurgy in order to ensure the market growth of this sector and competitiveness against alternative production techniques. One of the more promising routes able to achieve this is to aim for components with higher densities. LÄS MER