Sökning: "Combination therapy."
Visar resultat 1 - 5 av 581 avhandlingar innehållade orden Combination therapy..
1. Precision medicine and targeted therapy : Turning the tables on cancer
Sammanfattning : An extended understanding of the molecular characteristics of cancer has led to a revolution within the field of precision medicine. This thesis explores the utilization of two targets for precision medicine, namely, CD44v6 and murine double-minute 2 and X (MDM2/X). LÄS MER
2. Strategies for optimisation of 177Lu-octreotate therapy – exploring local administration and combination therapy regimens
Sammanfattning : Neuroendocrine tumours (NETs) are a group of heterogeneous tumour types that originate in hormone-producing organs. Patients with NETs are often diagnosed after the primary tumour has metastasised. LÄS MER
3. Data-driven modeling of combination therapy in oncology
Sammanfattning : This thesis contains two manuscripts: Tumor Static Concentration Curves in Combination Therapy and Extending the Tumor Static Concentration Curve to Exposure - A Combination Therapy Example with Radiation Therapy. There is also an introductory chapter presenting some basic facts necessary to understand the appended manuscripts. LÄS MER
4. Nonlinear Mixed Effects Modeling of Combination Therapies in Oncology
Sammanfattning : It has been shown that simultaneous administration of two or more anticancer agents can have a beneficial effect on cancer patients. This type of treatment is called combination therapy and is nowadays commonly used in the fight against cancer. LÄS MER
5. Pharmacometrics for Combination Therapy in Oncology Within and Across Species Variability in Time Series and Time-to-event Data
Sammanfattning : Mathematical modeling is an integral part of the drug development process. Models are developed to describe tumor dynamics or drug concentration to answer questions such as: What concentration is required to reach the desirable treatment outcome? What drug dose and frequency should a drug prescription specify to achieve this concentration? Models are also used for simulation, reducing the need to perform additional animal trials. LÄS MER