Sökning: "Colorectal cancer"

Visar resultat 6 - 10 av 279 avhandlingar innehållade orden Colorectal cancer.

  1. 6. Mismatch Repair Deficient Cancer Diagnostic Aspects in Colorectal Cancer and the Role of Urological Cancer in Lynch Syndrome

    Detta är en avhandling från Department of Oncology, Clinical Sciences, Lund University

    Författare :Patrick Joost; Lund University.; Lunds universitet.; Lund University.; Lunds universitet.; [2015]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Mismatch repair; Lynch syndrome; immunohistochemistry; microsatellite instability; heterogeneity; cumulative incidence; colorectal cancer; urothelial cancer; prostate cancer; renal cell cancer;

    Sammanfattning : Mismatch repair (MMR) deficiency is carcinogenic and can either have somatic/sporadic causes (i.e. epigenetic silencing or somatic inactivation) or hereditary causes (Lynch syndrome due to a germline mutation in one of the MMR genes ¬- MLH1, MSH2, MSH6, PMS2). LÄS MER

  2. 7. Colorectal Cancer Aspects of Heredity, Prognosis and Tumour Markers

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Lana Ghanipour; Uppsala universitet.; [2014]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; colorectal cancer; heredity; Tryptophanyl t-RNA synthetase; microsatellite instability; SP-PLA; prognosis; biomarkers;

    Sammanfattning : Colorectal cancer (CRC) is one of the most common cancer types and leading causes of cancer death worldwide. Since CRC is a heterogenic disease, there is a demand for increased knowledge of the underlying genetic and epigenetic mechanisms. The aim of this thesis was to investigate heredity and potential tumour markers in relation to prognosis. LÄS MER

  3. 8. Genomic Profiling, Mutations and Deranged Signaling in Esophageal Cancer and Hereditary Colorectal Cancer

    Detta är en avhandling från Lund University: Faculty of Medicine

    Författare :Anna Isinger Ekstrand; Lund University.; Lunds universitet.; [2010]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Esophageal cancer; hereditary cancer; HNPCC; copy number analysis; CGH; gene expression; Wnt; PIK3CA; CHEK2; gastric cancer; colorectal cancer;

    Sammanfattning : Esophageal cancer and colorectal cancer represents two major types of gastrointestinal tumors. Though refined surgery and introduction of novel chemotherapeutics have improved outcome, more than 2500 Swedes die from these diseases every year. Novel markers for early diagnosis, prognosis and treatment prediction are therefore needed. LÄS MER

  4. 9. Chemoradiation in Gastrointestinal Cancer

    Detta är en avhandling från Lund University: Faculty of Medicine

    Författare :Adalsteinn Gunnlaugsson; Lund University.; Lunds universitet.; [2010]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biliary tract cancer; capecitabine; cholangiocarcinoma; chemoradiation; colon cancer; enteritis 5-fluorouracil; gallbladder cancer; oxaliplatin; pancreatic cancer; rectal cancer.;

    Sammanfattning : Locally advanced inextirpable gastrointestinal cancer has poor prognosis and is associated with high morbidity. One treatment option is to use radiotherapy, often combined with chemotherapy (chemoradiation), either as preoperative treatment to facilitate surgery or in the palliative setting to relieve symptoms. LÄS MER

  5. 10. From Tissue to Mutations Genetic Profiling of Colorectal Cancer

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Lucy Mathot; Uppsala universitet.; [2014]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Nucleic acid extraction; genotyping; targeted sequencing; mutation analysis; colorectal cancer; metastatic disease; Medical Science; Medicinsk vetenskap;

    Sammanfattning : Comprehensive characterisation of the mutational landscapes of solid tumours is a multistep process involving the collection of suitable samples, the extraction of nucleic acids and the preparation of these materials for mutational analyses. In this thesis, I aimed to develop a streamlined process for the analysis of colorectal cancer (CRC) patient samples in order to identify novel mutations that hallmark the development of advanced disease. LÄS MER