Sökning: "Collagen induced arthritis CIA"

Visar resultat 21 - 25 av 59 avhandlingar innehållade orden Collagen induced arthritis CIA.

  1. 21. The Role of Fc Gamma Receptors in Experimental Arthritis

    Författare :Maria Andrén; Sandra Kleinau; Birgitta Heyman; Roland Jonsson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immunology; Rheumatoid arthritis; Antibodies; Fc receptors; Complement; Transgenic Knockout mice; Immunologi; Immunology; Immunologi;

    Sammanfattning : Induction of collagen-induced arthritis (CIA), an animal model for human rheumatoid arthritis, is dependent on anti-collagen type II (CII) antibodies. The effector mechanism by which autoantibodies contribute to inflammatory reactions in autoimmune diseases is not well understood. LÄS MER

  3. 22. Studies on novel immunosuppressive agents in experimental arthritis

    Författare :Thi Ngoc Dzung Dang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Artocarpus Tonkinensis; Collagen-induced arthritis; apoptosis; immunosuppression;

    Sammanfattning : Rheumatoid Arthritis (RA) is a chronic inflammatory disease of the joints. The hallmark of RA is persisting inflammation in diarthrodial joints with infiltration of leukocytes, thickening of the synovial lining layer and synovial pannus formation. LÄS MER

  4. 23. Posttranslational modification of collagen type II : effects on antigen-specific T-cell tolerance and autoreactivity in collagen-induced arthritis

    Författare :Patrick Merky; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Rheumatoid arthritis (RA) is a common chronic inflammatory disease affecting peripheral joints in approximately 1% of the world population. Immunization of susceptible strains with CII, leads to development of collagen-induced arthritis (CIA), an animal model for RA. LÄS MER

  5. 24. Plasmin : a potent pro-inflammatory factor

    Författare :Yongzhi Guo; Tor Ny; Dick Heinegård; Umeå universitet; []
    Nyckelord :LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; plasmin; inflammation; rheumatoid arthritis; bacterial arthritis; infection; sepsis; cytokine; signal transduction; Pathology; Patologi;

    Sammanfattning : Plasmin, the central molecule of the plasminogen activator system, is a broad-spectrum serine protease. Plasmin is important for the degradation of fibrin and other components of the extracellular matrix (ECM) during a number of physiological and pathological processes. LÄS MER

  7. 25. Modulation of Autoimmunity by Linomide treatment or interference with costimulation

    Författare :Annamaria C Tellander; Institutionen för experimentell medicinsk vetenskap; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; oncology; Cytology; collagen-induced arthritis; CD28; CD40; antigen presenting cells; Linomide; thymocytes; cancerology; Cytologi; onkologi; cancer;

    Sammanfattning : Linomide is a potent immunomodulator that has been shown to inhibit autoimmunity in several animal models of autoimmune disease. We have approached the cellular and molecular mechanism of Linomide by investigating its effect on thymocyte development and its capacity to modulate the expression of activation markers on antigen presenting cells (APCs). LÄS MER