Sökning: "Collagen induced arthritis CIA"

Visar resultat 16 - 20 av 59 avhandlingar innehållade orden Collagen induced arthritis CIA.

1. 16. Arthritis and immune-mediated bone loss - role of estrogen signalling pathways

   Författare :Cecilia Engdahl; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Arthritis; Bone; Estrogen;

   Sammanfattning : Objective: Rheumatoid arthritis (RA) is associated with immune-mediated bone loss and thereby increased risk for fractures. Estrogen and selective estrogen receptor modulators (SERMs) ameliorate not only the incidence and progression of experimental RA but also the immune-mediated bone loss. LÄS MER

3. 17. From disease to genes in animal models of rheumatoid arthritis and multiple sclerosis

   Författare :Therese Lindvall; Immunologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; mice; animal models; autoimmunity; CIA; EAE; RA; MS;

   Sammanfattning : Rheumatoid arthritis (RA) and multiple sclerosis (MS) are complex inflammatory autoimmune diseases. The aetiology is largely unknown but the risk of developing disease is dependent on both genetic and environmental factors. LÄS MER

4. 18. The role of S100A4 protein as a regulator of inflammation and bone metabolism in experimental arthritis

   Författare :Li Bian; Göteborgs universitet; []
   Nyckelord :S100A4; arthritis; animal model; bone; inflammation;

   Sammanfattning : S100A4 belongs to the family of calcium-binding S100 proteins and modulates cell proliferation, cytoskeletal rearrangement, cell motility, and angiogenesis. Increased levels of S100A4 expression correlate with high incidence of metastasis of cancers. LÄS MER

5. 19. Autoantibody recognition of collagen type II in arthritis

   Författare :Ingrid Lindh; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Autoantibodies against collagen type II (CII), a protein localized in the joint cartilage, play a major role in collagen-induced arthritis (CIA), one of the most commonly used animal models for rheumatoid arthritis (RA). The studies included in this thesis were undertaken to elucidate structural and functional requirements for B and T cells to recognize native CII structures during experimental arthritis as well as in human RA. LÄS MER

7. 20. Cytokine regulation in rodents with experimental arthritis

   Författare :Åsa Boström Müssener; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :collagen-induced arthritis; oil-induced arthritis; IL-2; IL-4; TNFa; IFNy; TGFß;

   Sammanfattning : The general aim of this project has been to try to elucidate the mechanisms behind induction of arthritis by using in situ hybridization and immunohistochemical methods to analyse the dynamics of the cytokine network in vivo, in the peripheral Iymphoid system and in the joints of rodents with collagen-induced arthritis (CIA)and oil-induced arthritis (OIA). We first examined the kinetics of cytokine gene expression in vivo, in the draining Iymph nodes of DA rats following immunization with rat type II collagen (RCII) emulsified in Freund's incomplete adjuvant oil (FIA) or with only FIA, which are regimens that induce CIA and OIA, respectively. LÄS MER