Sökning: "Collagen artros"
Visar resultat 1 - 5 av 7 avhandlingar innehållade orden Collagen artros.
1. The role of leucine-rich repeat glycoproteins/proteoglycans in the assembly of collagen matrices
Sammanfattning : The properties of different connective tissues depend on the synthesis and assembly of macromolecular structures composed of collagen and other extracellular matrix components. Mechanisms modulating these events play important roles in the formation of a functional tissue. LÄS MER
2. The collagen fibrillar network: Sequential degradation of its constituents by tissue metalloproteinases
Sammanfattning : The cartilage matrix is made up of a fibrillar meshwork comprising type II collagen and other associated proteins. One main function of this network is to retain the large aggregating proteoglycan, aggrecan, a vital component in the regulation of fluid flux in cartilage. LÄS MER
3. Studies on chondrocyte integrins and mechanical signaling
Sammanfattning : Integrins are a family of cell surface receptors known to bind matrix proteins and to mediate signals such as mechanical signals between the cell and the surrounding matrix. We have studied integrins that are expressed by chondrocytes, with specific focus on the integrins that interact with the cartilage matrix protein collagen type II. LÄS MER
4. Fibromodulin and chondroadherin in connective tissue homeostasis
Sammanfattning : Connective tissue contains a prominent extracellular matrix (ECM), which provides for physiological and mechanical properties. Intra- and inter-molecular interactions between proteins in this ECM provide for the formation of molecular networks. These interactions determine the shape of the tissue as well as cell behavior. LÄS MER
5. Functional analysis of the alpha10beta1 integrin
Sammanfattning : The aim of this thesis was to study the function of the integrin a10b1. Integrins mediate signals between cells and their environment and regulate several cellular processes such as cell migration, proliferation and differentiation. LÄS MER