Sökning: "Colin B. Reese"

Hittade 1 avhandling innehållade orden Colin B. Reese.

1. 1. Studies towards a method for incorporation of 3'-deoxy-3'-C-methylenephosphonate linkages into oligonucleotides

   Författare :Anna Winqvist; Colin B. Reese; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Organisk kemi; Organic Chemistry; organisk kemi;

   Sammanfattning : Synthetic strategies towards 3’-deoxy-3’-C-methylenephosphinate building blocks were explored. The key transformations involved stereoselective hydroboration of 1-[2-O-(tert-butyldimethylsilyl-5-O-(4-methoxytrityl)-3-deoxy-3-C-methylene- ß -D-erythro-pentofuranosyl]uracil to give the corresponding 3’-deoxy-3’-C- hydroxymethyl derivative with ribo-configuration, as well as the further conversion into a precursor with a suitable leaving group, e. LÄS MER