Sökning: "CoA transferase"

Visar resultat 1 - 5 av 9 avhandlingar innehållade orden CoA transferase.

  1. 1. Formyl-coenzyme : a transferase, structure and enzymatic mechanism

    Författare :Stefano Ricagno; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :X-ray crystallography; oxalate degradation; Oxalobacter; CoA transferase; interlocked dimer; anhydride.;

    Sammanfattning : Background: Formyl-CoA transferase (Frc) is the first enzyme in a two enzyme pathway responsible for oxalate degradation in Oxalobacter formigenes. This bacterium is a constitutive part of human intestinal flora. Its role as an oxalate scavenger is very important, reports have shown a strong connection between the disappearance of 0. LÄS MER

  2. 2. The type-I acyl-CoA thioesterase/acyltransferase gene family : linking structure to function

    Författare :James O'Byrne; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Type-I acyl-CoA thioesterase acyltransferase gene family; structure function relationship; nueleophilic elbow; esterase transferase activity;

    Sammanfattning : Acyl-CoA thioesterases hydrolyse acyl-CoAs to non-esterified fatty acids and coenzyme A (CoASH), thereby regulating intracellular levels of these compounds. We have recently identified and initiated characterisation of a novel, unique gene family of acyl-CoA thioesterases/acyltransferases, called the Type-I acyl-CoA thioesterase/acyltransferase gene family. LÄS MER

  3. 3. Structural enzymology of oxalate degradation in Oxalobacter formigenes

    Författare :Catrine L Berthold; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Oxalic acid, as one of nature's most highly oxidised compounds, is toxic to most organisms. It is introduced in the human body in the diet but also as a waste product of cellular metabolism. Mammals do not posses the ability to degrade oxalate and must excrete it in the urine or through the intestine. LÄS MER

  4. 4. Amino acid conjugation of fatty acids as a novel pathway in lipid metabolism

    Författare :Sarah-Jayne Reilly; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Peroxisomes are cell organelles that play an important role in the metabolism of a variety of lipids including very long chain fatty acids, dicarboxylic acids, bile acids, and xenobiotic carboxylic acids to name a few. To accomplish these tasks peroxisomes contain many proteins involved in lipid metabolism including members of the Type I acyl-CoA thioesterase/acyltransferase protein family. LÄS MER

  5. 5. Anaerobic degradation of phenol and related aromatics

    Författare :Anna Karlsson; James M. Tiedje; Linköpings universitet; []
    Nyckelord :SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; Aromatic compunds; anaerobic degradation; Fysik; Kemi; INTERDISCIPLINARY RESEARCH AREAS; TVÄRVETENSKAPLIGA FORSKNINGSOMRÅDEN;

    Sammanfattning : Phenol and other simple aromatic compounds have been found in water leached from landfills, showing that these types of compounds could be either present in disposed waste, or released from it via transformation and degradation processes. Hence, the fate anddegradation potential of such compounds under landfilling conditions is of great concern. LÄS MER